ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response: ΔNp63α may cause genomic instability in epithelial stem cells

BACKGROUND: The DNA damage response (DDR) is a mechanism that protects cells against radiation-induced oxidative DNA damage by causing cell cycle arrest and apoptosis. TP63 is a member of the tumour suppressor TP53 gene family, and ΔNp63α, a TP63 splicing variant, is constitutively expressed in the...

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Detalles Bibliográficos
Autores principales: Kudo, Ken-ichi, Tsuyama, Naohiro, Nagata, Kento, Imaoka, Tatsuhiko, Iizuka, Daisuke, Sugai-Takahashi, Misaki, Muramatsu, Moe, Sakai, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667649/
https://www.ncbi.nlm.nih.gov/pubmed/36380314
http://dx.doi.org/10.1186/s13014-022-02139-7

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