A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action

CK2 is a ubiquitous protein kinase with an anti-apoptotic role and is found to be overexpressed in multiple cancer types. To this end, the inhibition of CK2 is of great interest with regard to the development of novel anti-cancer therapeutics. ATP-site inhibition of CK2 is possible; however, this ty...

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Detalles Bibliográficos
Autores principales: Brear, Paul, De Fusco, Claudia, Atkinson, Eleanor L., Iegre, Jessica, Francis-Newton, Nicola J., Venkitaraman, Ashok R., Hyvönen, Marko, Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667777/
https://www.ncbi.nlm.nih.gov/pubmed/36426237
http://dx.doi.org/10.1039/d2md00161f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667777/
https://www.ncbi.nlm.nih.gov/pubmed/36426237
http://dx.doi.org/10.1039/d2md00161f

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