Cargando…
Outcomes After Liver Transplantation With Incidental Cholangiocarcinoma
Cholangiocarcinoma (CCA) is currently a contraindication to liver transplantation (LT) in the United Kingdom (UK). Incidental CCA occurs rarely in some patients undergoing LT. We report on retrospective outcomes of patients with incidental CCA from six UK LT centres. Cases were identified from patho...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667791/ https://www.ncbi.nlm.nih.gov/pubmed/36406780 http://dx.doi.org/10.3389/ti.2022.10802 |
_version_ | 1784831784446328832 |
---|---|
author | Safdar, Nawaz Z. Hakeem, Abdul R. Faulkes, Rosemary James, Fiona Mason, Lisa Masson, Steven Powell, James Rowe, Ian Shetty, Shishir Jones, Rebecca Spiers, Harry V. M. Halliday, Neil Baker, Jack Thorburn, Douglas Prasad, Raj Parker, Richard |
author_facet | Safdar, Nawaz Z. Hakeem, Abdul R. Faulkes, Rosemary James, Fiona Mason, Lisa Masson, Steven Powell, James Rowe, Ian Shetty, Shishir Jones, Rebecca Spiers, Harry V. M. Halliday, Neil Baker, Jack Thorburn, Douglas Prasad, Raj Parker, Richard |
author_sort | Safdar, Nawaz Z. |
collection | PubMed |
description | Cholangiocarcinoma (CCA) is currently a contraindication to liver transplantation (LT) in the United Kingdom (UK). Incidental CCA occurs rarely in some patients undergoing LT. We report on retrospective outcomes of patients with incidental CCA from six UK LT centres. Cases were identified from pathology records. Data regarding tumour characteristics and post-transplant survival were collected. CCA was classified by TNM staging and anatomical location. 95 patients who underwent LT between 1988–2020 were identified. Median follow-up after LT was 2.1 years (14 days-18.6 years). Most patients were male (68.4%), median age at LT was 53 (IQR 46-62), and the majority had underlying PSC (61%). Overall median survival after LT was 4.4 years. Survival differed by tumour site: 1-, 3-, and 5-year estimated survival was 82.1%, 68.7%, and 57.1%, respectively, in intrahepatic CCA (n = 40) and 58.5%, 42.6%, and 30.2% in perihilar CCA (n = 42; p = 0.06). 1-, 3-, and 5-year estimated survival was 95.8%, 86.5%, and 80.6%, respectively, in pT1 tumours (28.2% of cohort), and 65.8%, 44.7%, and 31.1%, respectively, in pT2-4 (p = 0.018). Survival after LT for recipients with incidental CCA is inferior compared to usual outcomes for LT in the United Kingdom. LT for earlier stage CCA has similar survival to LT for hepatocellular cancer, and intrahepatic CCAs have better survival compared to perihilar CCAs. These observations may support LT for CCA in selected cases. |
format | Online Article Text |
id | pubmed-9667791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96677912022-11-17 Outcomes After Liver Transplantation With Incidental Cholangiocarcinoma Safdar, Nawaz Z. Hakeem, Abdul R. Faulkes, Rosemary James, Fiona Mason, Lisa Masson, Steven Powell, James Rowe, Ian Shetty, Shishir Jones, Rebecca Spiers, Harry V. M. Halliday, Neil Baker, Jack Thorburn, Douglas Prasad, Raj Parker, Richard Transpl Int Health Archive Cholangiocarcinoma (CCA) is currently a contraindication to liver transplantation (LT) in the United Kingdom (UK). Incidental CCA occurs rarely in some patients undergoing LT. We report on retrospective outcomes of patients with incidental CCA from six UK LT centres. Cases were identified from pathology records. Data regarding tumour characteristics and post-transplant survival were collected. CCA was classified by TNM staging and anatomical location. 95 patients who underwent LT between 1988–2020 were identified. Median follow-up after LT was 2.1 years (14 days-18.6 years). Most patients were male (68.4%), median age at LT was 53 (IQR 46-62), and the majority had underlying PSC (61%). Overall median survival after LT was 4.4 years. Survival differed by tumour site: 1-, 3-, and 5-year estimated survival was 82.1%, 68.7%, and 57.1%, respectively, in intrahepatic CCA (n = 40) and 58.5%, 42.6%, and 30.2% in perihilar CCA (n = 42; p = 0.06). 1-, 3-, and 5-year estimated survival was 95.8%, 86.5%, and 80.6%, respectively, in pT1 tumours (28.2% of cohort), and 65.8%, 44.7%, and 31.1%, respectively, in pT2-4 (p = 0.018). Survival after LT for recipients with incidental CCA is inferior compared to usual outcomes for LT in the United Kingdom. LT for earlier stage CCA has similar survival to LT for hepatocellular cancer, and intrahepatic CCAs have better survival compared to perihilar CCAs. These observations may support LT for CCA in selected cases. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9667791/ /pubmed/36406780 http://dx.doi.org/10.3389/ti.2022.10802 Text en Copyright © 2022 Safdar, Hakeem, Faulkes, James, Mason, Masson, Powell, Rowe, Shetty, Jones, Spiers, Halliday, Baker, Thorburn, Prasad and Parker. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Health Archive Safdar, Nawaz Z. Hakeem, Abdul R. Faulkes, Rosemary James, Fiona Mason, Lisa Masson, Steven Powell, James Rowe, Ian Shetty, Shishir Jones, Rebecca Spiers, Harry V. M. Halliday, Neil Baker, Jack Thorburn, Douglas Prasad, Raj Parker, Richard Outcomes After Liver Transplantation With Incidental Cholangiocarcinoma |
title | Outcomes After Liver Transplantation With Incidental Cholangiocarcinoma |
title_full | Outcomes After Liver Transplantation With Incidental Cholangiocarcinoma |
title_fullStr | Outcomes After Liver Transplantation With Incidental Cholangiocarcinoma |
title_full_unstemmed | Outcomes After Liver Transplantation With Incidental Cholangiocarcinoma |
title_short | Outcomes After Liver Transplantation With Incidental Cholangiocarcinoma |
title_sort | outcomes after liver transplantation with incidental cholangiocarcinoma |
topic | Health Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667791/ https://www.ncbi.nlm.nih.gov/pubmed/36406780 http://dx.doi.org/10.3389/ti.2022.10802 |
work_keys_str_mv | AT safdarnawazz outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT hakeemabdulr outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT faulkesrosemary outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT jamesfiona outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT masonlisa outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT massonsteven outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT powelljames outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT roweian outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT shettyshishir outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT jonesrebecca outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT spiersharryvm outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT hallidayneil outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT bakerjack outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT thorburndouglas outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT prasadraj outcomesafterlivertransplantationwithincidentalcholangiocarcinoma AT parkerrichard outcomesafterlivertransplantationwithincidentalcholangiocarcinoma |