Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis

OBJECTIVE: Bleeding ulcers and erosions are hallmarks of active ulcerative colitis (UC). However, the mechanisms controlling bleeding and mucosal haemostasis remain elusive. DESIGN: We used high-resolution endoscopy and colon tissue samples of active UC (n = 36) as well as experimental models of phy...

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Detalles Bibliográficos
Autores principales: Leppkes, Moritz, Lindemann, Aylin, Gößwein, Stefanie, Paulus, Susanne, Roth, Dominik, Hartung, Anne, Liebing, Eva, Zundler, Sebastian, Gonzalez-Acera, Miguel, Patankar, Jay V, Mascia, Fabrizio, Scheibe, Kristina, Hoffmann, Markus, Uderhardt, Stefan, Schauer, Christine, Foersch, Sebastian, Neufert, Clemens, Vieth, Michael, Schett, Georg, Atreya, Raja, Kühl, Anja A, Bleich, Andre, Becker, Christoph, Herrmann, Martin, Neurath, Markus F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Inflammatory Bowel Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667856/
https://www.ncbi.nlm.nih.gov/pubmed/34862250
http://dx.doi.org/10.1136/gutjnl-2021-324725

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