Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues

Molecular glues represent an evolution in drug discovery, however, targeted stabilization of protein complexes remains challenging, owing to a paucity of drug design rules. The functional mapping of hotspots has been critical to protein–protein interaction (PPI) inhibitor research, however, the orth...

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Detalles Bibliográficos
Autores principales: Somsen, Bente A., Craenmehr, Fenna W. B., Liu, Wei-Hong W., Koops, Auke A., Pennings, Marloes A. M., Visser, Emira J., Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667936/
https://www.ncbi.nlm.nih.gov/pubmed/36425501
http://dx.doi.org/10.1039/d2sc04662h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667936/
https://www.ncbi.nlm.nih.gov/pubmed/36425501
http://dx.doi.org/10.1039/d2sc04662h

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