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Inferring parameters of cancer evolution in chronic lymphocytic leukemia
As a cancer develops, its cells accrue new mutations, resulting in a heterogeneous, complex genomic profile. We make use of this heterogeneity to derive simple, analytic estimates of parameters driving carcinogenesis and reconstruct the timeline of selective events following initiation of an individ...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668150/ https://www.ncbi.nlm.nih.gov/pubmed/36331987 http://dx.doi.org/10.1371/journal.pcbi.1010677 |