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Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA

Malaria during pregnancy is a major global health problem caused by infection with Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected erythrocytes in the placenta. Here, erythrocytes infected by late blood-stage parasites adhere to placental chondroitin sulphate...

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Detalles Bibliográficos
Autores principales:	Raghavan, Sai Sundar Rajan, Dagil, Robert, Lopez-Perez, Mary, Conrad, Julian, Bassi, Maria Rosaria, Quintana, Maria del Pilar, Choudhary, Swati, Gustavsson, Tobias, Wang, Yong, Gourdon, Pontus, Ofori, Michael Fokuo, Christensen, Sebastian Boje, Minja, Daniel Thomas Remias, Schmiegelow, Christentze, Nielsen, Morten Agertoug, Barfod, Lea, Hviid, Lars, Salanti, Ali, Lavstsen, Thomas, Wang, Kaituo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668162/ https://www.ncbi.nlm.nih.gov/pubmed/36383559 http://dx.doi.org/10.1371/journal.ppat.1010924

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