Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1

The Omicron BA.1 variant emerged in late 2021 and quickly spread across the world. Compared to the earlier SARS-CoV-2 variants, BA.1 has many mutations, some of which are known to enable antibody escape. Many of these antibody-escape mutations individually decrease the spike receptor-binding domain...

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Detalles Bibliográficos
Autores principales: Moulana, Alief, Dupic, Thomas, Phillips, Angela M., Chang, Jeffrey, Nieves, Serafina, Roffler, Anne A., Greaney, Allison J., Starr, Tyler N., Bloom, Jesse D., Desai, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668218/
https://www.ncbi.nlm.nih.gov/pubmed/36384919
http://dx.doi.org/10.1038/s41467-022-34506-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668218/
https://www.ncbi.nlm.nih.gov/pubmed/36384919
http://dx.doi.org/10.1038/s41467-022-34506-z

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