BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes

The BCG (Bacille Calmette-Guérin) vaccine, introduced 100 years ago for tuberculosis prevention, has emerging therapeutic off-target benefits for autoimmunity. In randomized controlled trials, BCG vaccinations were shown to gradually improve two autoimmune conditions, type 1 diabetes (T1D) and multi...

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Detalles Bibliográficos
Autores principales: Takahashi, Hiroyuki, Kühtreiber, Willem M., Keefe, Ryan C., Lee, Amanda H., Aristarkhova, Anna, Dias, Hans F., Ng, Nathan, Nelson, Kacie J., Bien, Stephanie, Scheffey, Danielle, Faustman, Denise L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668301/
https://www.ncbi.nlm.nih.gov/pubmed/36383663
http://dx.doi.org/10.1126/sciadv.abq7240

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