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Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases

Controlled primary cell wall remodeling allows plant growth under stressful conditions, but how these changes are conveyed to adjust cellulose synthesis is not understood. Here, we identify the TETRATRICOPEPTIDE THIOREDOXIN-LIKE (TTL) proteins as new members of the cellulose synthase complex (CSC) a...

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Autores principales: Kesten, Christopher, García-Moreno, Álvaro, Amorim-Silva, Vítor, Menna, Alexandra, Castillo, Araceli G., Percio, Francisco, Armengot, Laia, Ruiz-Lopez, Noemi, Jaillais, Yvon, Sánchez-Rodríguez, Clara, Botella, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668322/
https://www.ncbi.nlm.nih.gov/pubmed/36383676
http://dx.doi.org/10.1126/sciadv.abq6971
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author Kesten, Christopher
García-Moreno, Álvaro
Amorim-Silva, Vítor
Menna, Alexandra
Castillo, Araceli G.
Percio, Francisco
Armengot, Laia
Ruiz-Lopez, Noemi
Jaillais, Yvon
Sánchez-Rodríguez, Clara
Botella, Miguel A.
author_facet Kesten, Christopher
García-Moreno, Álvaro
Amorim-Silva, Vítor
Menna, Alexandra
Castillo, Araceli G.
Percio, Francisco
Armengot, Laia
Ruiz-Lopez, Noemi
Jaillais, Yvon
Sánchez-Rodríguez, Clara
Botella, Miguel A.
author_sort Kesten, Christopher
collection PubMed
description Controlled primary cell wall remodeling allows plant growth under stressful conditions, but how these changes are conveyed to adjust cellulose synthesis is not understood. Here, we identify the TETRATRICOPEPTIDE THIOREDOXIN-LIKE (TTL) proteins as new members of the cellulose synthase complex (CSC) and describe their unique and hitherto unknown dynamic association with the CSC under cellulose-deficient conditions. We find that TTLs are essential for maintaining cellulose synthesis under high-salinity conditions, establishing a stress-resilient cortical microtubule array, and stabilizing CSCs at the plasma membrane. To fulfill these functions, TTLs interact with CELLULOSE SYNTHASE 1 (CESA1) and engage with cortical microtubules to promote their polymerization. We propose that TTLs function as bridges connecting stress perception with dynamic regulation of cellulose biosynthesis at the plasma membrane.
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spelling pubmed-96683222022-11-29 Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases Kesten, Christopher García-Moreno, Álvaro Amorim-Silva, Vítor Menna, Alexandra Castillo, Araceli G. Percio, Francisco Armengot, Laia Ruiz-Lopez, Noemi Jaillais, Yvon Sánchez-Rodríguez, Clara Botella, Miguel A. Sci Adv Biomedicine and Life Sciences Controlled primary cell wall remodeling allows plant growth under stressful conditions, but how these changes are conveyed to adjust cellulose synthesis is not understood. Here, we identify the TETRATRICOPEPTIDE THIOREDOXIN-LIKE (TTL) proteins as new members of the cellulose synthase complex (CSC) and describe their unique and hitherto unknown dynamic association with the CSC under cellulose-deficient conditions. We find that TTLs are essential for maintaining cellulose synthesis under high-salinity conditions, establishing a stress-resilient cortical microtubule array, and stabilizing CSCs at the plasma membrane. To fulfill these functions, TTLs interact with CELLULOSE SYNTHASE 1 (CESA1) and engage with cortical microtubules to promote their polymerization. We propose that TTLs function as bridges connecting stress perception with dynamic regulation of cellulose biosynthesis at the plasma membrane. American Association for the Advancement of Science 2022-11-16 /pmc/articles/PMC9668322/ /pubmed/36383676 http://dx.doi.org/10.1126/sciadv.abq6971 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Kesten, Christopher
García-Moreno, Álvaro
Amorim-Silva, Vítor
Menna, Alexandra
Castillo, Araceli G.
Percio, Francisco
Armengot, Laia
Ruiz-Lopez, Noemi
Jaillais, Yvon
Sánchez-Rodríguez, Clara
Botella, Miguel A.
Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases
title Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases
title_full Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases
title_fullStr Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases
title_full_unstemmed Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases
title_short Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases
title_sort peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668322/
https://www.ncbi.nlm.nih.gov/pubmed/36383676
http://dx.doi.org/10.1126/sciadv.abq6971
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