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Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study

BACKGROUND/AIMS: The prospective Crohn’s Disease Clinical Network and Cohort Study is a nationwide multicenter cohort study of patients with Crohn’s disease (CD) in Korea, aiming to prospectively investigate the clinical features and long-term prognosis associated with CD. METHODS: Patients diagnose...

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Autores principales: Hong, Seung Wook, Ye, Byong Duk, Cheon, Jae Hee, Lee, Ji Hyun, Koo, Ja Seol, Jang, Byung Ik, Lee, Kang-Moon, Kim, You Sun, Kim, Tae Oh, Im, Jong Pil, Song, Geun Am, Jung, Sung-Ae, Kim, Hyun Soo, Park, Dong Il, Kim, Hyun-Soo, Huh, Kyu Chan, Kim, Young-Ho, Cha, Jae Myung, Seo, Geom Seog, Choi, Chang Hwan, Song, Hyun Joo, Baik, Gwang Ho, Kim, Ji Won, Shin, Sung Jae, Park, Young Sook, Lee, Chang Kyun, Lee, Jun, Jung, Sung Hee, Jung, Yunho, Park, Sung Chul, Joo, Young-Eun, Jeen, Yoon Tae, Han, Dong Soo, Yang, Suk-Kyun, Kim, Hyo Jong, Kim, Won Ho, Kim, Joo Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668509/
https://www.ncbi.nlm.nih.gov/pubmed/35321956
http://dx.doi.org/10.5009/gnl210299
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author Hong, Seung Wook
Ye, Byong Duk
Cheon, Jae Hee
Lee, Ji Hyun
Koo, Ja Seol
Jang, Byung Ik
Lee, Kang-Moon
Kim, You Sun
Kim, Tae Oh
Im, Jong Pil
Song, Geun Am
Jung, Sung-Ae
Kim, Hyun Soo
Park, Dong Il
Kim, Hyun-Soo
Huh, Kyu Chan
Kim, Young-Ho
Cha, Jae Myung
Seo, Geom Seog
Choi, Chang Hwan
Song, Hyun Joo
Baik, Gwang Ho
Kim, Ji Won
Shin, Sung Jae
Park, Young Sook
Lee, Chang Kyun
Lee, Jun
Jung, Sung Hee
Jung, Yunho
Park, Sung Chul
Joo, Young-Eun
Jeen, Yoon Tae
Han, Dong Soo
Yang, Suk-Kyun
Kim, Hyo Jong
Kim, Won Ho
Kim, Joo Sung
author_facet Hong, Seung Wook
Ye, Byong Duk
Cheon, Jae Hee
Lee, Ji Hyun
Koo, Ja Seol
Jang, Byung Ik
Lee, Kang-Moon
Kim, You Sun
Kim, Tae Oh
Im, Jong Pil
Song, Geun Am
Jung, Sung-Ae
Kim, Hyun Soo
Park, Dong Il
Kim, Hyun-Soo
Huh, Kyu Chan
Kim, Young-Ho
Cha, Jae Myung
Seo, Geom Seog
Choi, Chang Hwan
Song, Hyun Joo
Baik, Gwang Ho
Kim, Ji Won
Shin, Sung Jae
Park, Young Sook
Lee, Chang Kyun
Lee, Jun
Jung, Sung Hee
Jung, Yunho
Park, Sung Chul
Joo, Young-Eun
Jeen, Yoon Tae
Han, Dong Soo
Yang, Suk-Kyun
Kim, Hyo Jong
Kim, Won Ho
Kim, Joo Sung
author_sort Hong, Seung Wook
collection PubMed
description BACKGROUND/AIMS: The prospective Crohn’s Disease Clinical Network and Cohort Study is a nationwide multicenter cohort study of patients with Crohn’s disease (CD) in Korea, aiming to prospectively investigate the clinical features and long-term prognosis associated with CD. METHODS: Patients diagnosed with CD between January 2009 and September 2019 were prospectively enrolled. They were divided into two cohorts according to the year of diagnosis cohort 1 (diagnosed between 2009 and 2011) versus cohort 2 (between 2012 and 2019). RESULTS: A total of 1,175 patients were included, and the median follow-up duration was 68 months (interquartile range, 39.0 to 91.0 months). The treatment-free durations for thiopurines (p<0.001) and anti-tumor necrosis factor agents (p=0.018) of cohort 2 were shorter than those of cohort 1. Among 887 patients with B1 behavior at diagnosis, 149 patients (16.8%) progressed to either B2 or B3 behavior during follow-up. Early use of thiopurine was associated with a reduced risk of behavioral progression (adjusted hazard ratio [aHR], 0.69; 95% confidence interval [CI], 0.50 to 0.90), and family history of inflammatory bowel disease was associated with an increased risk of behavioral progression (aHR, 2.29; 95% CI, 1.16 to 4.50). One hundred forty-one patients (12.0%) underwent intestinal resection, and the intestinal resection-free survival time was significantly longer in cohort 2 than in cohort 1 (p=0.003). The early use of thiopurines (aHR, 0.35; 95% CI, 0.23 to 0.51) was independently associated with a reduced risk of intestinal resection. CONCLUSIONS: The prognosis of CD in Korea appears to have improved over time, as evidenced by the decreasing intestinal resection rate. Early use of thiopurines was associated with an improved prognosis represented by a reduced risk of intestinal resection.
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spelling pubmed-96685092022-11-29 Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study Hong, Seung Wook Ye, Byong Duk Cheon, Jae Hee Lee, Ji Hyun Koo, Ja Seol Jang, Byung Ik Lee, Kang-Moon Kim, You Sun Kim, Tae Oh Im, Jong Pil Song, Geun Am Jung, Sung-Ae Kim, Hyun Soo Park, Dong Il Kim, Hyun-Soo Huh, Kyu Chan Kim, Young-Ho Cha, Jae Myung Seo, Geom Seog Choi, Chang Hwan Song, Hyun Joo Baik, Gwang Ho Kim, Ji Won Shin, Sung Jae Park, Young Sook Lee, Chang Kyun Lee, Jun Jung, Sung Hee Jung, Yunho Park, Sung Chul Joo, Young-Eun Jeen, Yoon Tae Han, Dong Soo Yang, Suk-Kyun Kim, Hyo Jong Kim, Won Ho Kim, Joo Sung Gut Liver Original Article BACKGROUND/AIMS: The prospective Crohn’s Disease Clinical Network and Cohort Study is a nationwide multicenter cohort study of patients with Crohn’s disease (CD) in Korea, aiming to prospectively investigate the clinical features and long-term prognosis associated with CD. METHODS: Patients diagnosed with CD between January 2009 and September 2019 were prospectively enrolled. They were divided into two cohorts according to the year of diagnosis cohort 1 (diagnosed between 2009 and 2011) versus cohort 2 (between 2012 and 2019). RESULTS: A total of 1,175 patients were included, and the median follow-up duration was 68 months (interquartile range, 39.0 to 91.0 months). The treatment-free durations for thiopurines (p<0.001) and anti-tumor necrosis factor agents (p=0.018) of cohort 2 were shorter than those of cohort 1. Among 887 patients with B1 behavior at diagnosis, 149 patients (16.8%) progressed to either B2 or B3 behavior during follow-up. Early use of thiopurine was associated with a reduced risk of behavioral progression (adjusted hazard ratio [aHR], 0.69; 95% confidence interval [CI], 0.50 to 0.90), and family history of inflammatory bowel disease was associated with an increased risk of behavioral progression (aHR, 2.29; 95% CI, 1.16 to 4.50). One hundred forty-one patients (12.0%) underwent intestinal resection, and the intestinal resection-free survival time was significantly longer in cohort 2 than in cohort 1 (p=0.003). The early use of thiopurines (aHR, 0.35; 95% CI, 0.23 to 0.51) was independently associated with a reduced risk of intestinal resection. CONCLUSIONS: The prognosis of CD in Korea appears to have improved over time, as evidenced by the decreasing intestinal resection rate. Early use of thiopurines was associated with an improved prognosis represented by a reduced risk of intestinal resection. Editorial Office of Gut and Liver 2022-11-15 2022-03-24 /pmc/articles/PMC9668509/ /pubmed/35321956 http://dx.doi.org/10.5009/gnl210299 Text en Copyright © Gut and Liver. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hong, Seung Wook
Ye, Byong Duk
Cheon, Jae Hee
Lee, Ji Hyun
Koo, Ja Seol
Jang, Byung Ik
Lee, Kang-Moon
Kim, You Sun
Kim, Tae Oh
Im, Jong Pil
Song, Geun Am
Jung, Sung-Ae
Kim, Hyun Soo
Park, Dong Il
Kim, Hyun-Soo
Huh, Kyu Chan
Kim, Young-Ho
Cha, Jae Myung
Seo, Geom Seog
Choi, Chang Hwan
Song, Hyun Joo
Baik, Gwang Ho
Kim, Ji Won
Shin, Sung Jae
Park, Young Sook
Lee, Chang Kyun
Lee, Jun
Jung, Sung Hee
Jung, Yunho
Park, Sung Chul
Joo, Young-Eun
Jeen, Yoon Tae
Han, Dong Soo
Yang, Suk-Kyun
Kim, Hyo Jong
Kim, Won Ho
Kim, Joo Sung
Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
title Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
title_full Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
title_fullStr Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
title_full_unstemmed Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
title_short Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
title_sort clinical features and long-term prognosis of crohn’s disease in korea: results from the prospective connect study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668509/
https://www.ncbi.nlm.nih.gov/pubmed/35321956
http://dx.doi.org/10.5009/gnl210299
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