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Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas
Adamantinomatous craniopharyngioma (ACPs) are rare embryonic tumors and often involve the hypothalamus. The underlying neural substrate of the hypothalamic involvement (HI)-related cognitive decline in patients with ACP is still unclear. We aimed to combine the multi-modal neuroimaging and histologi...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668598/ https://www.ncbi.nlm.nih.gov/pubmed/36201952 http://dx.doi.org/10.1016/j.nicl.2022.103215 |
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author | Kang, Jie Cao, Lei Yuan, Taoyang Jin, Lu He, Yanjiao Liu, Xing Zhang, Cuiping Chen, Nan Ma, Guofo Qiao, Ning Zhang, Bochao Wu, Wentao Shi, Yuanyu Gao, Hua Li, Chuzhong Zhang, Yazhuo Zuo, Zhentao Gui, Songbai |
author_facet | Kang, Jie Cao, Lei Yuan, Taoyang Jin, Lu He, Yanjiao Liu, Xing Zhang, Cuiping Chen, Nan Ma, Guofo Qiao, Ning Zhang, Bochao Wu, Wentao Shi, Yuanyu Gao, Hua Li, Chuzhong Zhang, Yazhuo Zuo, Zhentao Gui, Songbai |
author_sort | Kang, Jie |
collection | PubMed |
description | Adamantinomatous craniopharyngioma (ACPs) are rare embryonic tumors and often involve the hypothalamus. The underlying neural substrate of the hypothalamic involvement (HI)-related cognitive decline in patients with ACP is still unclear. We aimed to combine the multi-modal neuroimaging and histological characteristics of the ACP to explore the potential neural substrate of the HI-related cognitive decline. 45 patients with primary ACPs (invasive, 23; noninvasive, 22) and 52 healthy control subjects (HCs) were admitted to the cross-sectional study. No significant difference in cognitive domains was observed between HCs and patients with noninvasive ACPs (NACP). Patients with invasive ACPs (IACP) showed significantly lower working memory performance (WM, p = 0.002) than patients with NACP. The WM decline was correlated with the disruption of the medial temporal lobe (MTL) subsystem in the default mode network (DMN) (r = 0.45, p = 0.004). The increased radial diffusivity of the fornix, indicating demyelinating process, was correlated with the disruption of the MTL subsystem (r = -0.48, p = 0.002). Our study demonstrated that the fornix alterations link DMN disruption to HI-related cognitive decline in patients with ACPs. ACPs that invade the hypothalamus can provide a natural disease model to investigate the potential neural substrate of HI-related cognitive decline. |
format | Online Article Text |
id | pubmed-9668598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96685982022-11-17 Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas Kang, Jie Cao, Lei Yuan, Taoyang Jin, Lu He, Yanjiao Liu, Xing Zhang, Cuiping Chen, Nan Ma, Guofo Qiao, Ning Zhang, Bochao Wu, Wentao Shi, Yuanyu Gao, Hua Li, Chuzhong Zhang, Yazhuo Zuo, Zhentao Gui, Songbai Neuroimage Clin Regular Article Adamantinomatous craniopharyngioma (ACPs) are rare embryonic tumors and often involve the hypothalamus. The underlying neural substrate of the hypothalamic involvement (HI)-related cognitive decline in patients with ACP is still unclear. We aimed to combine the multi-modal neuroimaging and histological characteristics of the ACP to explore the potential neural substrate of the HI-related cognitive decline. 45 patients with primary ACPs (invasive, 23; noninvasive, 22) and 52 healthy control subjects (HCs) were admitted to the cross-sectional study. No significant difference in cognitive domains was observed between HCs and patients with noninvasive ACPs (NACP). Patients with invasive ACPs (IACP) showed significantly lower working memory performance (WM, p = 0.002) than patients with NACP. The WM decline was correlated with the disruption of the medial temporal lobe (MTL) subsystem in the default mode network (DMN) (r = 0.45, p = 0.004). The increased radial diffusivity of the fornix, indicating demyelinating process, was correlated with the disruption of the MTL subsystem (r = -0.48, p = 0.002). Our study demonstrated that the fornix alterations link DMN disruption to HI-related cognitive decline in patients with ACPs. ACPs that invade the hypothalamus can provide a natural disease model to investigate the potential neural substrate of HI-related cognitive decline. Elsevier 2022-09-30 /pmc/articles/PMC9668598/ /pubmed/36201952 http://dx.doi.org/10.1016/j.nicl.2022.103215 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Kang, Jie Cao, Lei Yuan, Taoyang Jin, Lu He, Yanjiao Liu, Xing Zhang, Cuiping Chen, Nan Ma, Guofo Qiao, Ning Zhang, Bochao Wu, Wentao Shi, Yuanyu Gao, Hua Li, Chuzhong Zhang, Yazhuo Zuo, Zhentao Gui, Songbai Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas |
title | Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas |
title_full | Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas |
title_fullStr | Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas |
title_full_unstemmed | Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas |
title_short | Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas |
title_sort | fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668598/ https://www.ncbi.nlm.nih.gov/pubmed/36201952 http://dx.doi.org/10.1016/j.nicl.2022.103215 |
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