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From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions

Focal lesions in both white and gray matter are characteristic of multiple sclerosis (MS). Histopathological studies have helped define the main underlying pathological processes involved in lesion formation and evolution, serving as a gold standard for many years. However, histopathology suffers fr...

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Autores principales: Kolb, Hadar, Al-Louzi, Omar, Beck, Erin S., Sati, Pascal, Absinta, Martina, Reich, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668624/
https://www.ncbi.nlm.nih.gov/pubmed/36170753
http://dx.doi.org/10.1016/j.nicl.2022.103194
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author Kolb, Hadar
Al-Louzi, Omar
Beck, Erin S.
Sati, Pascal
Absinta, Martina
Reich, Daniel S.
author_facet Kolb, Hadar
Al-Louzi, Omar
Beck, Erin S.
Sati, Pascal
Absinta, Martina
Reich, Daniel S.
author_sort Kolb, Hadar
collection PubMed
description Focal lesions in both white and gray matter are characteristic of multiple sclerosis (MS). Histopathological studies have helped define the main underlying pathological processes involved in lesion formation and evolution, serving as a gold standard for many years. However, histopathology suffers from an intrinsic bias resulting from over-reliance on tissue samples from late stages of the disease or atypical cases and is inadequate for routine patient assessment. Pathological-radiological correlative studies have established advanced MRI’s sensitivity to several relevant MS-pathological substrates and its practicality for assessing dynamic changes and following lesions over time. This review focuses on novel imaging techniques that serve as biomarkers of critical pathological substrates of MS lesions: the central vein, chronic inflammation, remyelination and repair, and cortical lesions. For each pathological process, we address the correlative value of MRI to MS pathology, its contribution in elucidating MS pathology in vivo, and the clinical utility of the imaging biomarker.
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spelling pubmed-96686242022-11-18 From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions Kolb, Hadar Al-Louzi, Omar Beck, Erin S. Sati, Pascal Absinta, Martina Reich, Daniel S. Neuroimage Clin Regular Article Focal lesions in both white and gray matter are characteristic of multiple sclerosis (MS). Histopathological studies have helped define the main underlying pathological processes involved in lesion formation and evolution, serving as a gold standard for many years. However, histopathology suffers from an intrinsic bias resulting from over-reliance on tissue samples from late stages of the disease or atypical cases and is inadequate for routine patient assessment. Pathological-radiological correlative studies have established advanced MRI’s sensitivity to several relevant MS-pathological substrates and its practicality for assessing dynamic changes and following lesions over time. This review focuses on novel imaging techniques that serve as biomarkers of critical pathological substrates of MS lesions: the central vein, chronic inflammation, remyelination and repair, and cortical lesions. For each pathological process, we address the correlative value of MRI to MS pathology, its contribution in elucidating MS pathology in vivo, and the clinical utility of the imaging biomarker. Elsevier 2022-09-14 /pmc/articles/PMC9668624/ /pubmed/36170753 http://dx.doi.org/10.1016/j.nicl.2022.103194 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Kolb, Hadar
Al-Louzi, Omar
Beck, Erin S.
Sati, Pascal
Absinta, Martina
Reich, Daniel S.
From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions
title From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions
title_full From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions
title_fullStr From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions
title_full_unstemmed From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions
title_short From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions
title_sort from pathology to mri and back: clinically relevant biomarkers of multiple sclerosis lesions
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668624/
https://www.ncbi.nlm.nih.gov/pubmed/36170753
http://dx.doi.org/10.1016/j.nicl.2022.103194
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