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Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction

Previous studies have found that peripheral vestibular dysfunction is associated with altered volumes in different brain structures, especially in the hippocampus. However, published evidence is conflicting. Based on previous findings, we compared hippocampal volume, as well as supramarginal, superi...

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Autores principales: Schöne, Corina G., Rebsamen, Michael, Wyssen, Gerda, Rummel, Christian, Wagner, Franca, Vibert, Dominique, Mast, Fred W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668627/
https://www.ncbi.nlm.nih.gov/pubmed/36209619
http://dx.doi.org/10.1016/j.nicl.2022.103212
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author Schöne, Corina G.
Rebsamen, Michael
Wyssen, Gerda
Rummel, Christian
Wagner, Franca
Vibert, Dominique
Mast, Fred W.
author_facet Schöne, Corina G.
Rebsamen, Michael
Wyssen, Gerda
Rummel, Christian
Wagner, Franca
Vibert, Dominique
Mast, Fred W.
author_sort Schöne, Corina G.
collection PubMed
description Previous studies have found that peripheral vestibular dysfunction is associated with altered volumes in different brain structures, especially in the hippocampus. However, published evidence is conflicting. Based on previous findings, we compared hippocampal volume, as well as supramarginal, superior temporal, and postcentral gyrus in a sample of 55 patients with different conditions of peripheral vestibular dysfunction (bilateral, chronic unilateral, acute unilateral) to 39 age- and sex-matched healthy controls. In addition, we explored deviations in gray-matter volumes in hippocampal subfields. We also analysed correlations between morphometric data and visuo-spatial performance. Patients with vestibular dysfunction did not differ in total hippocampal volume from healthy controls. However, a reduced volume in the right presubiculum of the hippocampus and the left supramarginal gyrus was observed in patients with chronic and acute unilateral vestibular dysfunction, but not in patients with bilateral vestibular dysfunction. No association of altered volumes with visuo-spatial performance was found. An asymmetric vestibular input due to unilateral vestibular dysfunction might lead to reduced central brain volumes that are involved in vestibular processing.
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spelling pubmed-96686272022-11-18 Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction Schöne, Corina G. Rebsamen, Michael Wyssen, Gerda Rummel, Christian Wagner, Franca Vibert, Dominique Mast, Fred W. Neuroimage Clin Regular Article Previous studies have found that peripheral vestibular dysfunction is associated with altered volumes in different brain structures, especially in the hippocampus. However, published evidence is conflicting. Based on previous findings, we compared hippocampal volume, as well as supramarginal, superior temporal, and postcentral gyrus in a sample of 55 patients with different conditions of peripheral vestibular dysfunction (bilateral, chronic unilateral, acute unilateral) to 39 age- and sex-matched healthy controls. In addition, we explored deviations in gray-matter volumes in hippocampal subfields. We also analysed correlations between morphometric data and visuo-spatial performance. Patients with vestibular dysfunction did not differ in total hippocampal volume from healthy controls. However, a reduced volume in the right presubiculum of the hippocampus and the left supramarginal gyrus was observed in patients with chronic and acute unilateral vestibular dysfunction, but not in patients with bilateral vestibular dysfunction. No association of altered volumes with visuo-spatial performance was found. An asymmetric vestibular input due to unilateral vestibular dysfunction might lead to reduced central brain volumes that are involved in vestibular processing. Elsevier 2022-09-28 /pmc/articles/PMC9668627/ /pubmed/36209619 http://dx.doi.org/10.1016/j.nicl.2022.103212 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Schöne, Corina G.
Rebsamen, Michael
Wyssen, Gerda
Rummel, Christian
Wagner, Franca
Vibert, Dominique
Mast, Fred W.
Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction
title Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction
title_full Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction
title_fullStr Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction
title_full_unstemmed Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction
title_short Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction
title_sort hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668627/
https://www.ncbi.nlm.nih.gov/pubmed/36209619
http://dx.doi.org/10.1016/j.nicl.2022.103212
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