Cargando…

Marked Improvement in A1C Levels After Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Maintained Over 4 Years in Patients With Type 1 Diabetes

OBJECTIVE: This study aimed to demonstrate the effectiveness of long-term use of intermittently scanned continuous glucose monitoring (isCGM) in adult patients with type 1 diabetes. DESIGN AND METHODS: In this retrospective real-world study, 689 patients with type 1 diabetes who were >18 years of...

Descripción completa

Detalles Bibliográficos
Autores principales: Mustonen, Jyrki, Rautiainen, Päivi, Lamidi, Marja-Leena, Lavikainen, Piia, Martikainen, Janne, Laatikainen, Tiina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668726/
https://www.ncbi.nlm.nih.gov/pubmed/36545258
http://dx.doi.org/10.2337/ds21-0087
_version_ 1784831976345174016
author Mustonen, Jyrki
Rautiainen, Päivi
Lamidi, Marja-Leena
Lavikainen, Piia
Martikainen, Janne
Laatikainen, Tiina
author_facet Mustonen, Jyrki
Rautiainen, Päivi
Lamidi, Marja-Leena
Lavikainen, Piia
Martikainen, Janne
Laatikainen, Tiina
author_sort Mustonen, Jyrki
collection PubMed
description OBJECTIVE: This study aimed to demonstrate the effectiveness of long-term use of intermittently scanned continuous glucose monitoring (isCGM) in adult patients with type 1 diabetes. DESIGN AND METHODS: In this retrospective real-world study, 689 patients with type 1 diabetes who were >18 years of age and using isCGM were identified from the electronic patient records in North Karelia, Finland. A1C data were collected before and after the initiation of isCGM. The primary outcome was a change in the mean A1C over time after isCGM started. RESULTS: The greatest reductions in the mean A1C levels were observed 6 months (−0.54% [−5.9 mmol/mol], P <0.001) and 12 months (−0.42% [−4.6 mmol/mol], P <0.001) after the initiation of isCGM. Reduction in A1C remained significant for 4 years, although the mean reduction in A1C was −0.18% (−2.05 mmol/mol) (P = 0.009) at 48 months compared with baseline. In a subgroup analysis, patients with a baseline A1C >9% (75 mmol/mol) benefited the most from initiation of isCGM (reduction −0.97% [−10.6 mmol/mol], P <0.001, at 12 months and −0.92% [−10.1 mmol/mol], P <0.001, at 48 months). Neither sex nor age at the start of isCGM were correlated with A1C reduction. CONCLUSION: Use of isCGM improves A1C levels significantly in adult patients with type 1 diabetes. Significant reduction in A1C persisted over 4 years of use, although the effect diminished over time.
format Online
Article
Text
id pubmed-9668726
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-96687262022-12-20 Marked Improvement in A1C Levels After Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Maintained Over 4 Years in Patients With Type 1 Diabetes Mustonen, Jyrki Rautiainen, Päivi Lamidi, Marja-Leena Lavikainen, Piia Martikainen, Janne Laatikainen, Tiina Diabetes Spectr Feature Articles OBJECTIVE: This study aimed to demonstrate the effectiveness of long-term use of intermittently scanned continuous glucose monitoring (isCGM) in adult patients with type 1 diabetes. DESIGN AND METHODS: In this retrospective real-world study, 689 patients with type 1 diabetes who were >18 years of age and using isCGM were identified from the electronic patient records in North Karelia, Finland. A1C data were collected before and after the initiation of isCGM. The primary outcome was a change in the mean A1C over time after isCGM started. RESULTS: The greatest reductions in the mean A1C levels were observed 6 months (−0.54% [−5.9 mmol/mol], P <0.001) and 12 months (−0.42% [−4.6 mmol/mol], P <0.001) after the initiation of isCGM. Reduction in A1C remained significant for 4 years, although the mean reduction in A1C was −0.18% (−2.05 mmol/mol) (P = 0.009) at 48 months compared with baseline. In a subgroup analysis, patients with a baseline A1C >9% (75 mmol/mol) benefited the most from initiation of isCGM (reduction −0.97% [−10.6 mmol/mol], P <0.001, at 12 months and −0.92% [−10.1 mmol/mol], P <0.001, at 48 months). Neither sex nor age at the start of isCGM were correlated with A1C reduction. CONCLUSION: Use of isCGM improves A1C levels significantly in adult patients with type 1 diabetes. Significant reduction in A1C persisted over 4 years of use, although the effect diminished over time. American Diabetes Association 2022 2022-03-29 /pmc/articles/PMC9668726/ /pubmed/36545258 http://dx.doi.org/10.2337/ds21-0087 Text en © 2022 by the American Diabetes Association https://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/journals/pages/license.
spellingShingle Feature Articles
Mustonen, Jyrki
Rautiainen, Päivi
Lamidi, Marja-Leena
Lavikainen, Piia
Martikainen, Janne
Laatikainen, Tiina
Marked Improvement in A1C Levels After Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Maintained Over 4 Years in Patients With Type 1 Diabetes
title Marked Improvement in A1C Levels After Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Maintained Over 4 Years in Patients With Type 1 Diabetes
title_full Marked Improvement in A1C Levels After Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Maintained Over 4 Years in Patients With Type 1 Diabetes
title_fullStr Marked Improvement in A1C Levels After Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Maintained Over 4 Years in Patients With Type 1 Diabetes
title_full_unstemmed Marked Improvement in A1C Levels After Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Maintained Over 4 Years in Patients With Type 1 Diabetes
title_short Marked Improvement in A1C Levels After Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Maintained Over 4 Years in Patients With Type 1 Diabetes
title_sort marked improvement in a1c levels after initiation of intermittently scanned continuous glucose monitoring is maintained over 4 years in patients with type 1 diabetes
topic Feature Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668726/
https://www.ncbi.nlm.nih.gov/pubmed/36545258
http://dx.doi.org/10.2337/ds21-0087
work_keys_str_mv AT mustonenjyrki markedimprovementina1clevelsafterinitiationofintermittentlyscannedcontinuousglucosemonitoringismaintainedover4yearsinpatientswithtype1diabetes
AT rautiainenpaivi markedimprovementina1clevelsafterinitiationofintermittentlyscannedcontinuousglucosemonitoringismaintainedover4yearsinpatientswithtype1diabetes
AT lamidimarjaleena markedimprovementina1clevelsafterinitiationofintermittentlyscannedcontinuousglucosemonitoringismaintainedover4yearsinpatientswithtype1diabetes
AT lavikainenpiia markedimprovementina1clevelsafterinitiationofintermittentlyscannedcontinuousglucosemonitoringismaintainedover4yearsinpatientswithtype1diabetes
AT martikainenjanne markedimprovementina1clevelsafterinitiationofintermittentlyscannedcontinuousglucosemonitoringismaintainedover4yearsinpatientswithtype1diabetes
AT laatikainentiina markedimprovementina1clevelsafterinitiationofintermittentlyscannedcontinuousglucosemonitoringismaintainedover4yearsinpatientswithtype1diabetes