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A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling

mTORC1 and GCN2 are serine/threonine kinases that control how cells adapt to amino acid availability. mTORC1 responds to amino acids to promote translation and cell growth while GCN2 senses limiting amino acids to hinder translation via eIF2α phosphorylation. GCN2 is an appealing target for cancer t...

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Detalles Bibliográficos
Autores principales:	Brüggenthies, Johanna B., Fiore, Alessandra, Russier, Marion, Bitsina, Christina, Brötzmann, Julian, Kordes, Susanne, Menninger, Sascha, Wolf, Alexander, Conti, Elena, Eickhoff, Jan E., Murray, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668732/ https://www.ncbi.nlm.nih.gov/pubmed/36273589 http://dx.doi.org/10.1016/j.jbc.2022.102629

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