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Population-wide gene disruption in the murine lung epithelium via AAV-mediated delivery of CRISPR-Cas9 components

With the aim of expediting drug target discovery and validation for respiratory diseases, we developed an optimized method for in situ somatic gene disruption in murine lung epithelial cells via AAV6-mediated CRISPR-Cas9 delivery. Efficient gene editing was observed in lung type II alveolar epitheli...

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Detalles Bibliográficos
Autores principales:	Chen, Honglin, Durinck, Steffen, Patel, Hetal, Foreman, Oded, Mesh, Kathryn, Eastham, Jeffrey, Caothien, Roger, Newman, Robert J., Roose-Girma, Merone, Darmanis, Spyros, Warming, Soren, Lattanzi, Annalisa, Liang, Yuxin, Haley, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668740/ https://www.ncbi.nlm.nih.gov/pubmed/36419469 http://dx.doi.org/10.1016/j.omtm.2022.10.016

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