Fluorophore-conjugated 4-1BB antibody enables early detection of T-cell responses in inflammatory arthritis via NIRF imaging

PURPOSE: We first developed a 4-1BB-targeted optical probe, named IRDye-680RD-4-1BB mAb (monoclonal antibody), and evaluated its value for the detection of 4-1BB(+) activated T cells in vivo as well as the diagnosis of rheumatoid arthritis (RA) in an adjuvant-induced arthritis (AIA) mouse model. MET...

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Detalles Bibliográficos
Autores principales: Duan, Shao, Han, Chaozhe, Xia, Yifei, Jing, Chengwei, Dong, Bohan, Zhang, Xin, Wang, WeiWei, Wang, Yu, Zhang, Maomao, Li, Ping, Chen, Weiyu, Xiao, Zunyu, Li, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668804/
https://www.ncbi.nlm.nih.gov/pubmed/36069957
http://dx.doi.org/10.1007/s00259-022-05946-y

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