Cargando…

The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy

Skeletal muscle atrophy is a common complication in survivors of sepsis, which affects the respiratory and motor functions of patients, thus severely impacting their quality of life and long-term survival. Although several advances have been made in investigations on the pathogenetic mechanism of se...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yukun, Wang, Dongfang, Li, Tianyu, Yang, Fan, Li, Zhanfei, Bai, Xiangjun, Wang, Yuchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668849/
https://www.ncbi.nlm.nih.gov/pubmed/36405697
http://dx.doi.org/10.3389/fimmu.2022.1035709
_version_ 1784832002507145216
author Liu, Yukun
Wang, Dongfang
Li, Tianyu
Yang, Fan
Li, Zhanfei
Bai, Xiangjun
Wang, Yuchang
author_facet Liu, Yukun
Wang, Dongfang
Li, Tianyu
Yang, Fan
Li, Zhanfei
Bai, Xiangjun
Wang, Yuchang
author_sort Liu, Yukun
collection PubMed
description Skeletal muscle atrophy is a common complication in survivors of sepsis, which affects the respiratory and motor functions of patients, thus severely impacting their quality of life and long-term survival. Although several advances have been made in investigations on the pathogenetic mechanism of sepsis-induced skeletal muscle atrophy, the underlying mechanisms remain unclear. Findings from recent studies suggest that the nucleotide-binding and oligomerisation domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, a regulator of inflammation, may be crucial in the development of skeletal muscle atrophy. NLRP3 inhibitors contribute to the inhibition of catabolic processes, skeletal muscle atrophy and cachexia-induced inflammation. Here, we review the mechanisms by which NLRP3 mediates these responses and analyse how NLRP3 affects muscle wasting during inflammation.
format Online
Article
Text
id pubmed-9668849
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96688492022-11-18 The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy Liu, Yukun Wang, Dongfang Li, Tianyu Yang, Fan Li, Zhanfei Bai, Xiangjun Wang, Yuchang Front Immunol Immunology Skeletal muscle atrophy is a common complication in survivors of sepsis, which affects the respiratory and motor functions of patients, thus severely impacting their quality of life and long-term survival. Although several advances have been made in investigations on the pathogenetic mechanism of sepsis-induced skeletal muscle atrophy, the underlying mechanisms remain unclear. Findings from recent studies suggest that the nucleotide-binding and oligomerisation domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, a regulator of inflammation, may be crucial in the development of skeletal muscle atrophy. NLRP3 inhibitors contribute to the inhibition of catabolic processes, skeletal muscle atrophy and cachexia-induced inflammation. Here, we review the mechanisms by which NLRP3 mediates these responses and analyse how NLRP3 affects muscle wasting during inflammation. Frontiers Media S.A. 2022-11-03 /pmc/articles/PMC9668849/ /pubmed/36405697 http://dx.doi.org/10.3389/fimmu.2022.1035709 Text en Copyright © 2022 Liu, Wang, Li, Yang, Li, Bai and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Yukun
Wang, Dongfang
Li, Tianyu
Yang, Fan
Li, Zhanfei
Bai, Xiangjun
Wang, Yuchang
The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy
title The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy
title_full The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy
title_fullStr The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy
title_full_unstemmed The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy
title_short The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy
title_sort role of nlrp3 inflammasome in inflammation-related skeletal muscle atrophy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668849/
https://www.ncbi.nlm.nih.gov/pubmed/36405697
http://dx.doi.org/10.3389/fimmu.2022.1035709
work_keys_str_mv AT liuyukun theroleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT wangdongfang theroleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT litianyu theroleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT yangfan theroleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT lizhanfei theroleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT baixiangjun theroleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT wangyuchang theroleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT liuyukun roleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT wangdongfang roleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT litianyu roleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT yangfan roleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT lizhanfei roleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT baixiangjun roleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy
AT wangyuchang roleofnlrp3inflammasomeininflammationrelatedskeletalmuscleatrophy