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Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer

OBJECTIVES: Abbreviated breast MRI (AB-MRI) was introduced to reduce both examination and image reading times and to improve cost-effectiveness of breast cancer screening. The aim of this model-based economic study was to analyze the cost-effectiveness of full protocol breast MRI (FB-MRI) vs. AB-MRI...

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Autores principales: Tollens, Fabian, Baltzer, Pascal A. T., Dietzel, Matthias, Schnitzer, Moritz L., Schwarze, Vincent, Kunz, Wolfgang G., Rink, Johann, Rübenthaler, Johannes, Froelich, Matthias F., Schönberg, Stefan O., Kaiser, Clemens G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668927/
https://www.ncbi.nlm.nih.gov/pubmed/35482122
http://dx.doi.org/10.1007/s00330-022-08777-5
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author Tollens, Fabian
Baltzer, Pascal A. T.
Dietzel, Matthias
Schnitzer, Moritz L.
Schwarze, Vincent
Kunz, Wolfgang G.
Rink, Johann
Rübenthaler, Johannes
Froelich, Matthias F.
Schönberg, Stefan O.
Kaiser, Clemens G.
author_facet Tollens, Fabian
Baltzer, Pascal A. T.
Dietzel, Matthias
Schnitzer, Moritz L.
Schwarze, Vincent
Kunz, Wolfgang G.
Rink, Johann
Rübenthaler, Johannes
Froelich, Matthias F.
Schönberg, Stefan O.
Kaiser, Clemens G.
author_sort Tollens, Fabian
collection PubMed
description OBJECTIVES: Abbreviated breast MRI (AB-MRI) was introduced to reduce both examination and image reading times and to improve cost-effectiveness of breast cancer screening. The aim of this model-based economic study was to analyze the cost-effectiveness of full protocol breast MRI (FB-MRI) vs. AB-MRI in screening women with dense breast tissue for breast cancer. METHODS: Decision analysis and a Markov model were designed to model the cumulative costs and effects of biennial screening in terms of quality-adjusted life years (QALYs) from a US healthcare system perspective. Model input parameters for a cohort of women with dense breast tissue were adopted from recent literature. The impact of varying AB-MRI costs per examination as well as specificity on the resulting cost-effectiveness was modeled within deterministic sensitivity analyses. RESULTS: At an assumed cost per examination of $ 263 for AB-MRI (84% of the cost of a FB-MRI examination), the discounted cumulative costs of both MR-based strategies accounted comparably. Reducing the costs of AB-MRI below $ 259 (82% of the cost of a FB-MRI examination, respectively), the incremental cost-effectiveness ratio of FB-MRI exceeded the willingness to pay threshold and the AB-MRI-strategy should be considered preferable in terms of cost-effectiveness. CONCLUSIONS: Our preliminary findings indicate that AB-MRI may be considered cost-effective compared to FB-MRI for screening women with dense breast tissue for breast cancer, as long as the costs per examination do not exceed 82% of the cost of a FB-MRI examination. KEY POINTS: • Cost-effectiveness of abbreviated breast MRI is affected by reductions in specificity and resulting false positive findings and increased recall rates. • Abbreviated breast MRI may be cost-effective up to a cost per examination of 82% of the cost of a full protocol examination. • Abbreviated breast MRI could be an economically preferable alternative to full protocol breast MRI in screening women with dense breast tissue.
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spelling pubmed-96689272022-11-18 Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer Tollens, Fabian Baltzer, Pascal A. T. Dietzel, Matthias Schnitzer, Moritz L. Schwarze, Vincent Kunz, Wolfgang G. Rink, Johann Rübenthaler, Johannes Froelich, Matthias F. Schönberg, Stefan O. Kaiser, Clemens G. Eur Radiol Breast OBJECTIVES: Abbreviated breast MRI (AB-MRI) was introduced to reduce both examination and image reading times and to improve cost-effectiveness of breast cancer screening. The aim of this model-based economic study was to analyze the cost-effectiveness of full protocol breast MRI (FB-MRI) vs. AB-MRI in screening women with dense breast tissue for breast cancer. METHODS: Decision analysis and a Markov model were designed to model the cumulative costs and effects of biennial screening in terms of quality-adjusted life years (QALYs) from a US healthcare system perspective. Model input parameters for a cohort of women with dense breast tissue were adopted from recent literature. The impact of varying AB-MRI costs per examination as well as specificity on the resulting cost-effectiveness was modeled within deterministic sensitivity analyses. RESULTS: At an assumed cost per examination of $ 263 for AB-MRI (84% of the cost of a FB-MRI examination), the discounted cumulative costs of both MR-based strategies accounted comparably. Reducing the costs of AB-MRI below $ 259 (82% of the cost of a FB-MRI examination, respectively), the incremental cost-effectiveness ratio of FB-MRI exceeded the willingness to pay threshold and the AB-MRI-strategy should be considered preferable in terms of cost-effectiveness. CONCLUSIONS: Our preliminary findings indicate that AB-MRI may be considered cost-effective compared to FB-MRI for screening women with dense breast tissue for breast cancer, as long as the costs per examination do not exceed 82% of the cost of a FB-MRI examination. KEY POINTS: • Cost-effectiveness of abbreviated breast MRI is affected by reductions in specificity and resulting false positive findings and increased recall rates. • Abbreviated breast MRI may be cost-effective up to a cost per examination of 82% of the cost of a full protocol examination. • Abbreviated breast MRI could be an economically preferable alternative to full protocol breast MRI in screening women with dense breast tissue. Springer Berlin Heidelberg 2022-04-28 2022 /pmc/articles/PMC9668927/ /pubmed/35482122 http://dx.doi.org/10.1007/s00330-022-08777-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Breast
Tollens, Fabian
Baltzer, Pascal A. T.
Dietzel, Matthias
Schnitzer, Moritz L.
Schwarze, Vincent
Kunz, Wolfgang G.
Rink, Johann
Rübenthaler, Johannes
Froelich, Matthias F.
Schönberg, Stefan O.
Kaiser, Clemens G.
Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer
title Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer
title_full Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer
title_fullStr Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer
title_full_unstemmed Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer
title_short Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer
title_sort economic potential of abbreviated breast mri for screening women with dense breast tissue for breast cancer
topic Breast
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668927/
https://www.ncbi.nlm.nih.gov/pubmed/35482122
http://dx.doi.org/10.1007/s00330-022-08777-5
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