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The progressive ratio and fixed ratio 1 schedules of cocaine self-administration in rats convey the same information

Progressive ratio (PR) schedules of drug delivery are used to determine the ‘motivational’ state of an animal and drug ‘reinforcing efficacy’. This widely held interpretation is supported mainly by the observation that the PR breakpoint (BP) is proportional to the unit dose of self-administered drug...

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Detalles Bibliográficos
Autores principales: Tsibulsky, Vladimir L., Norman, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668967/
https://www.ncbi.nlm.nih.gov/pubmed/36385347
http://dx.doi.org/10.1038/s41598-022-24173-x