Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation

Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment. The mechanism of phospholipid modulation of any pLGIC is not well understood. We demonstrate that the model pLGIC, ELIC (Erwinia ligand-gated ion channel), is positively modulate...

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Detalles Bibliográficos
Autores principales: Petroff, John T., Dietzen, Noah M., Santiago-McRae, Ezry, Deng, Brett, Washington, Maya S., Chen, Lawrence J., Trent Moreland, K., Deng, Zengqin, Rau, Michael, Fitzpatrick, James A. J., Yuan, Peng, Joseph, Thomas T., Hénin, Jérôme, Brannigan, Grace, Cheng, Wayland W. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668969/
https://www.ncbi.nlm.nih.gov/pubmed/36385237
http://dx.doi.org/10.1038/s41467-022-34813-5

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