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First-in-human phase Ia study of the PI3Kα inhibitor CYH33 in patients with solid tumors

PIK3CA mutations are highly prevalent in solid tumors. Targeting phosphatidylinositol 3-kinase α is therefore an attractive strategy for treating cancers harboring PIK3CA mutations. Here, we report the results from a phase Ia, open label, dose-escalation and -expansion study (NCT03544905) of CYH33,...

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Detalles Bibliográficos
Autores principales:	Wei, Xiao-Li, Liu, Fu-Rong, Liu, Ji-Hong, Zhao, Hong-Yun, Zhang, Yang, Wang, Zhi-Qiang, Qiu, Miao-Zhen, Xu, Fei, Yu, Qiu-Qiong, Du, Yi-Wu, Shi, Yan-Xia, Wang, De-Sheng, Wang, Feng-Hua, Xu, Rui-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669016/ https://www.ncbi.nlm.nih.gov/pubmed/36385120 http://dx.doi.org/10.1038/s41467-022-34782-9

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