Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy

Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy necessitates optimization and maintenance of activated effector T cells (Teff). We prospectively collected and applied multi-omic analyses to paired pre- and post-treatment PDAC specimens collected in a platform neoadjuvant study of gr...

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Detalles Bibliográficos
Autores principales: Li, Keyu, Tandurella, Joseph A., Gai, Jessica, Zhu, Qingfeng, Lim, Su Jin, Thomas, Dwayne L., Xia, Tao, Mo, Guanglan, Mitchell, Jacob T., Montagne, Janelle, Lyman, Melissa, Danilova, Ludmila V., Zimmerman, Jacquelyn W., Kinny-Köster, Benedict, Zhang, Tengyi, Chen, Linda, Blair, Alex B., Heumann, Thatcher, Parkinson, Rose, Durham, Jennifer N., Narang, Amol K., Anders, Robert A., Wolfgang, Christopher L., Laheru, Daniel A., He, Jin, Osipov, Arsen, Thompson, Elizabeth D., Wang, Hao, Fertig, Elana J., Jaffee, Elizabeth M., Zheng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669212/
https://www.ncbi.nlm.nih.gov/pubmed/36306792
http://dx.doi.org/10.1016/j.ccell.2022.10.001

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