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NKB cells: A double-edged sword against inflammatory diseases

Interferon-γ (IFN-γ)-producing natural killer (NK) cells and innate lymphoid cells (ILCs) activate the adaptive system’s B and T cells in response to pathogenic invasion; however, how these cells are activated during infections is not yet fully understood. In recent years, a new lymphocyte populatio...

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Detalles Bibliográficos
Autores principales: Tandel, Nikunj, Negi, Sushmita, Tyagi, Rajeev K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669376/
https://www.ncbi.nlm.nih.gov/pubmed/36405684
http://dx.doi.org/10.3389/fimmu.2022.972435
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author Tandel, Nikunj
Negi, Sushmita
Tyagi, Rajeev K.
author_facet Tandel, Nikunj
Negi, Sushmita
Tyagi, Rajeev K.
author_sort Tandel, Nikunj
collection PubMed
description Interferon-γ (IFN-γ)-producing natural killer (NK) cells and innate lymphoid cells (ILCs) activate the adaptive system’s B and T cells in response to pathogenic invasion; however, how these cells are activated during infections is not yet fully understood. In recent years, a new lymphocyte population referred to as “natural killer-like B (NKB) cells”, expressing the characteristic markers of innate NK cells and adaptive B cells, has been identified in both the spleen and mesenteric lymph nodes during infectious and inflammatory pathologies. NKB cells produce IL-18 and IL-12 cytokines during the early phases of microbial infection, differentiating them from conventional NK and B cells. Emerging evidence indicates that NKB cells play key roles in clearing microbial infections. In addition, NKB cells contribute to inflammatory responses during infectious and inflammatory diseases. Hence, the role of NKB cells in disease pathogenesis merits further study. An in-depth understanding of the phenotypic, effector, and functional properties of NKB cells may pave the way for the development of improved vaccines and therapeutics for infectious and inflammatory diseases.
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spelling pubmed-96693762022-11-18 NKB cells: A double-edged sword against inflammatory diseases Tandel, Nikunj Negi, Sushmita Tyagi, Rajeev K. Front Immunol Immunology Interferon-γ (IFN-γ)-producing natural killer (NK) cells and innate lymphoid cells (ILCs) activate the adaptive system’s B and T cells in response to pathogenic invasion; however, how these cells are activated during infections is not yet fully understood. In recent years, a new lymphocyte population referred to as “natural killer-like B (NKB) cells”, expressing the characteristic markers of innate NK cells and adaptive B cells, has been identified in both the spleen and mesenteric lymph nodes during infectious and inflammatory pathologies. NKB cells produce IL-18 and IL-12 cytokines during the early phases of microbial infection, differentiating them from conventional NK and B cells. Emerging evidence indicates that NKB cells play key roles in clearing microbial infections. In addition, NKB cells contribute to inflammatory responses during infectious and inflammatory diseases. Hence, the role of NKB cells in disease pathogenesis merits further study. An in-depth understanding of the phenotypic, effector, and functional properties of NKB cells may pave the way for the development of improved vaccines and therapeutics for infectious and inflammatory diseases. Frontiers Media S.A. 2022-11-03 /pmc/articles/PMC9669376/ /pubmed/36405684 http://dx.doi.org/10.3389/fimmu.2022.972435 Text en Copyright © 2022 Tandel, Negi and Tyagi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tandel, Nikunj
Negi, Sushmita
Tyagi, Rajeev K.
NKB cells: A double-edged sword against inflammatory diseases
title NKB cells: A double-edged sword against inflammatory diseases
title_full NKB cells: A double-edged sword against inflammatory diseases
title_fullStr NKB cells: A double-edged sword against inflammatory diseases
title_full_unstemmed NKB cells: A double-edged sword against inflammatory diseases
title_short NKB cells: A double-edged sword against inflammatory diseases
title_sort nkb cells: a double-edged sword against inflammatory diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669376/
https://www.ncbi.nlm.nih.gov/pubmed/36405684
http://dx.doi.org/10.3389/fimmu.2022.972435
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