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Mitochondrial topoisomerase 1 inhibition induces topological DNA damage and T cell dysfunction in patients with chronic viral infection

T cells are crucial for controlling viral infections; however, the mechanisms that dampen their responses during viral infections remain incompletely understood. Here, we studied the role and mechanisms of mitochondrial topoisomerase 1 (Top1mt) inhibition in mitochondrial dysfunction and T cell dysr...

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Detalles Bibliográficos
Autores principales:	Dang, Xindi, Cao, Dechao, Zhao, Juan, Schank, Madison, Khanal, Sushant, Nguyen, Lam Ngoc Thao, Wu, Xiao Y., Zhang, Yi, Zhang, Jinyu, Jiang, Yong, Ning, Shunbin, Wang, Ling, El Gazzar, Mohamed, Moorman, Jonathan P., Yao, Zhi Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669385/ https://www.ncbi.nlm.nih.gov/pubmed/36405960 http://dx.doi.org/10.3389/fcimb.2022.1026293

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