Rag2(−/−) accelerates lipofuscin accumulation in the brain: Implications for human stem cell brain transplantation studies

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Immunodeficient mice are widely used in human stem cell transplantation research. Recombination activating gene 1 (Rag1) deletion results in immunodeficiency and leads to accelerated aging in zebrafish with increased cytosolic accumulation of lipofuscin (LF). Unlike zebrafish, mammals have two homol...

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Detalles Bibliográficos
Autores principales: Jin, Mengmeng, Alam, Mahabub Maraj, Liu, Alice Y.-C., Jiang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669406/
https://www.ncbi.nlm.nih.gov/pubmed/36270284
http://dx.doi.org/10.1016/j.stemcr.2022.09.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669406/
https://www.ncbi.nlm.nih.gov/pubmed/36270284
http://dx.doi.org/10.1016/j.stemcr.2022.09.012

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