Stabilization of cell-cell adhesions prevents symmetry breaking and locks in pluripotency in 3D gastruloids

3D embryonic stem cell (ESC) aggregates self-organize into embryo-like structures named gastruloids that recapitulate the axial organization of post-implantation embryos. Crucial in this process is the symmetry-breaking event that leads to the emergence of asymmetry and spatially ordered structures...

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Detalles Bibliográficos
Autores principales: Cermola, Federica, Amoroso, Filomena, Saracino, Federica, Ibello, Eduardo, De Cesare, Dario, Fico, Annalisa, Cobellis, Gilda, Scalera, Enrica, Casiraghi, Costanza, D’Aniello, Cristina, Patriarca, Eduardo Jorge, Minchiotti, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669408/
https://www.ncbi.nlm.nih.gov/pubmed/36306780
http://dx.doi.org/10.1016/j.stemcr.2022.09.013

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