Cargando…

Dietary choline, via gut microbe- generated trimethylamine-N- oxide, aggravates chronic kidney disease-induced cardiac dysfunction by inhibiting hypoxia-induced factor 1α

Chronic kidney disease (CKD) is a global public health problem that shortens lifespan primarily by increasing the risk of cardiovascular diseases. Trimethylamine-N-oxide (TMAO), a gut microbiota-derived toxin produced by metabolizing high-choline or carnitine foods, is associated with cardiovascular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Feifei, Zhen, Xin, Liu, Zhuoliang, Chen, Xiaomei, Liu, Zhuanhua, Zhou, Miaomiao, Zhou, Zhanmei, Hu, Zheng, Zhu, Fengxin, Huang, Qiaobing, Zhang, Lei, Nie, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669413/ https://www.ncbi.nlm.nih.gov/pubmed/36407000 http://dx.doi.org/10.3389/fphys.2022.996166

Ejemplares similares

Hypoxia Aggravates Inactivity-Related Muscle Wasting
por: Debevec, Tadej, et al.
Publicado: (2018)

Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome
por: Li, Xingxing, et al.
Publicado: (2021)

Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms
por: Schugar, Rebecca C, et al.
Publicado: (2022)

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension
por: Jiang, Shan, et al.
Publicado: (2021)

Advanced glycation endproducts mediate chronic kidney injury with characteristic patterns in different stages
por: Huang, Xiaoxia, et al.
Publicado: (2022)

Effects of dietary rumen-protected choline supplementation on colostrum yields, quality, and choline metabolites from dairy cattle
por: Swartz, T.H., et al.
Publicado: (2022)

Gut microbiota dependant trimethylamine N-oxide and hypertension
por: Mutengo, Katongo H., et al.
Publicado: (2023)

Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide Contributes to Cardiac Dysfunction in Western Diet-Induced Obese Mice
por: Chen, Kui, et al.
Publicado: (2017)

Trimethylamine N-Oxide Exacerbates Renal Inflammation and Fibrosis in Rats With Diabetic Kidney Disease
por: Fang, Qing, et al.
Publicado: (2021)

Bifidobacterium breve and Bifidobacterium longum Attenuate Choline-Induced Plasma Trimethylamine N-Oxide Production by Modulating Gut Microbiota in Mice
por: Wang, Qianqian, et al.
Publicado: (2022)

The gene expression and bioinformatic analysis of choline trimethylamine-lyase (CutC) and its activating enzyme (CutD) for gut microbes and comparison with their TMA production levels
por: Ramireddy, Latha, et al.
Publicado: (2021)

Lack of Adrenomedullin Aggravates Acute TNBS-Induced Colitis Symptoms in Mice, Especially in Females
por: Martínez-Herrero, Sonia, et al.
Publicado: (2017)

Osteoprotegerin deficiency aggravates methionine–choline-deficient diet-induced nonalcoholic steatohepatitis in mice
por: Wu, Shaobo, et al.
Publicado: (2023)

Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis
por: Lei, Wenjing, et al.
Publicado: (2023)

Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome
por: Li, Xueling, et al.
Publicado: (2019)

Acute hypoxia induced dysregulation of clock-controlled ovary functions
por: Ding, Mengnan, et al.
Publicado: (2022)

Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate
por: Nagy, Annamária, et al.
Publicado: (2020)

BMSC Transplantation Aggravates Inflammation, Oxidative Stress, and Fibrosis and Impairs Skeletal Muscle Regeneration
por: Liu, Xiaoguang, et al.
Publicado: (2019)

Corrigendum: BMSC Transplantation Aggravates Inflammation, Oxidative Stress, and Fibrosis and Impairs Skeletal Muscle Regeneration
por: Liu, Xiaoguang, et al.
Publicado: (2019)

Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood
por: Du, Juan, et al.
Publicado: (2018)

Lack of Adrenomedullin Results in Microbiota Changes and Aggravates Azoxymethane and Dextran Sulfate Sodium-Induced Colitis in Mice
por: Martínez-Herrero, Sonia, et al.
Publicado: (2016)

Effect of Choline Forms and Gut Microbiota Composition on Trimethylamine-N-Oxide Response in Healthy Men
por: Cho, Clara E., et al.
Publicado: (2020)

Residual Risk of Trimethylamine‐N‐Oxide and Choline for Stroke Recurrence in Patients With Intensive Secondary Therapy
por: Xue, Jing, et al.
Publicado: (2022)

Finasteride Alleviates High Fat Associated Protein-Overload Nephropathy by Inhibiting Trimethylamine N-Oxide Synthesis and Regulating Gut Microbiota
por: Wang, Zuoyuan, et al.
Publicado: (2022)

Association of Choline Intake with Blood Pressure and Effects of Its Microbiota-Dependent Metabolite Trimethylamine-N-Oxide on Hypertension
por: He, Guo-dong, et al.
Publicado: (2022)

Protective effects of choline against hypoxia-induced injuries of vessels and endothelial cells
por: Zhang, Lian-Cheng, et al.
Publicado: (2017)

Hypoxia-Induced Oxidative Stress Modulation with Physical Activity
por: Debevec, Tadej, et al.
Publicado: (2017)

Role of the Receptor for Advanced Glycation End Products in Heat Stress-Induced Endothelial Hyperpermeability in Acute Lung Injury
por: Zhou, Gengbiao, et al.
Publicado: (2020)

Simultaneous quantification of trimethylamine N-oxide, trimethylamine, choline, betaine, creatinine, and propionyl-, acetyl-, and l-carnitine in clinical and food samples using HILIC-LC-MS
por: Hefni, Mohammed E, et al.
Publicado: (2021)

Multidrug Resistance-Associated Protein 2 Deficiency Aggravates Estrogen-Induced Impairment of Bile Acid Metabolomics in Rats
por: Alaei Faradonbeh, Fatemeh, et al.
Publicado: (2022)

Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes
por: Liu, Jing, et al.
Publicado: (2017)

IL-6/STAT3 Induced Neuron Apoptosis in Hypoxia by Downregulating ATF6 Expression
por: Zhou, Simin, et al.
Publicado: (2021)

Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults
por: Chen, Yu-ming, et al.
Publicado: (2016)

Trimethylamine N-oxide Supplementation Abolishes the Cardioprotective Effects of Voluntary Exercise in Mice Fed a Western Diet
por: Zhang, Hongqi, et al.
Publicado: (2017)

The Association between Trimethylamine N-Oxide and Its Predecessors Choline, L-Carnitine, and Betaine with Coronary Artery Disease and Artery Stenosis
por: Guo, Fei, et al.
Publicado: (2020)

Unlike Glycerophosphocholine or Choline Chloride, Dietary Phosphatidylcholine Does Not Increase Plasma Trimethylamine-N-Oxide Levels in Sprague-Dawley Rats
por: Shirouchi, Bungo, et al.
Publicado: (2022)

Short-Term Sustained Hypoxia Elevates Basal and Hypoxia-Induced Ventilation but Not the Carotid Body Chemoreceptor Activity in Rats
por: Flor, Karine C., et al.
Publicado: (2018)

Hypoxia-Inducible Factor Regulates Endothelial Metabolism in Cardiovascular Disease
por: Ullah, Karim, et al.
Publicado: (2021)

Hypoxia-related mechanisms inducing acute mountain sickness and migraine
por: Frank, Florian, et al.
Publicado: (2022)

Liver CEBPβ Modulates the Kynurenine Metabolism and Mediates the Motility for Hypoxia-Induced Central Fatigue in Mice
por: Yang, Fan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vm4ddlv77t0md2hi7i7oo8mjmq