Administration of granulocyte-macrophage colony-stimulating factor enhanced chimeric antigen receptor T-cell expansion and cellular immunity recovery without inducing cytokine release syndrome

BACKGROUND: Neutropenia and cytokine release syndrome (CRS) are two major toxicities of chimeric antigen receptor (CAR)-T cell therapy. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an ideal candidate treatment for neutropenia except for its potential aggravation of CRS. We hypothesiz...

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Detalles Bibliográficos
Autores principales: Jiang, Ying, Feng, Dan, Wang, Chun, Zhang, Yanlei, Zhao, Chuxian, Li, Su, Qin, Youwen, Chang, Alex H., Zhu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669452/
https://www.ncbi.nlm.nih.gov/pubmed/36405594
http://dx.doi.org/10.3389/fmed.2022.1042501

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