Case report of clindamycin graded challenge in an AIDS patient allergic to clindamycin

The aim of this study was to report the success of a clindamycin graded challenge. The patient was a 39-year-old human immunodeficiency virus-infected male with toxoplasmic encephalitis (TE) with a history of trimethoprim/sulfamethoxazole (TMP/SMX) and clindamycin allergy. He developed a reaction du...

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Detalles Bibliográficos
Autores principales: Raknoo, Thitinun, Sae-lim, Orawan, Pattharachayakul, Sutthiporn, Kanchanasuwan, Siripen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2022
Materias:
Educational & Teaching Material
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669470/
https://www.ncbi.nlm.nih.gov/pubmed/36452008
http://dx.doi.org/10.5415/apallergy.2022.12.e36
Descripción
Sumario:The aim of this study was to report the success of a clindamycin graded challenge. The patient was a 39-year-old human immunodeficiency virus-infected male with toxoplasmic encephalitis (TE) with a history of trimethoprim/sulfamethoxazole (TMP/SMX) and clindamycin allergy. He developed a reaction during TMP/SMX desensitization. Following the reaction, a graded challenge with clindamycin was performed in this study, and he became tolerant to clindamycin. No adverse drug reactions developed during the graded challenge. He successfully continued suppressive therapy with no further reactions or recurrences.

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