Cell-autonomous lipid-handling defects in Stargardt iPSC-derived retinal pigment epithelium cells

Stargardt retinopathy is an inherited form of macular degeneration caused by mutations in gene ABCA4 and characterized by the accumulation of lipid-rich deposits in the retinal pigment epithelium (RPE), RPE atrophy, and photoreceptor cell death. Inadequate mechanistic insights into pathophysiologica...

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Detalles Bibliográficos
Autores principales: Farnoodian, Mitra, Bose, Devika, Khristov, Vladimir, Susaimanickam, Praveen Joseph, Maddileti, Savitri, Mariappan, Indumathi, Abu-Asab, Mones, Campos, Maria, Villasmil, Rafael, Wan, Qin, Maminishkis, Arvydas, McGaughey, David, Barone, Francesca, Gundry, Rebekah L., Riordon, Daniel R., Boheler, Kenneth R., Sharma, Ruchi, Bharti, Kapil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669500/
https://www.ncbi.nlm.nih.gov/pubmed/36306781
http://dx.doi.org/10.1016/j.stemcr.2022.10.001

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