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Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting RIPK3-mediated necroptosis

Calcium oxalate (CaOx) crystals, as the predominant component of human kidney stones, can trigger excessive cell death and inflammation of renal tubular epithelial cells, involved in the pathogenesis of nephrocalcinosis. Necroptosis mediated by receptor-interacting protein kinase 3 (RIPK3) serves a...

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Detalles Bibliográficos
Autores principales:	Hou, Bingbing, Liu, Mingming, Chen, Yang, Ni, Weijian, Suo, Xiaoguo, Xu, Yuexian, He, Qiushi, Meng, Xiaoming, Hao, Zongyao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669592/ https://www.ncbi.nlm.nih.gov/pubmed/36408256 http://dx.doi.org/10.3389/fphar.2022.1041117

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