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注射用两性霉素B胆固醇硫酸酯复合物治疗血液系统恶性肿瘤合并侵袭性真菌病30例临床分析

OBJECTIVE: To assess the safety and effectiveness of amphotericin B cholesteryl sulfate complex for injection in the context of empirical and diagnostic antifungal therapy for patients with hematological malignancies in addition to invasive fungal illness. METHODS: This single-arm clinical study enr...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial office of Chinese Journal of Hematology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669624/
https://www.ncbi.nlm.nih.gov/pubmed/36709199
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2022.10.008
Descripción
Sumario:OBJECTIVE: To assess the safety and effectiveness of amphotericin B cholesteryl sulfate complex for injection in the context of empirical and diagnostic antifungal therapy for patients with hematological malignancies in addition to invasive fungal illness. METHODS: This single-arm clinical study enrolled 30 patients who received empirical and diagnostic-driven antifungal therapy for hematological malignancies combined with invasive fungal disease. The primary endpoint was safety. Response rate, fever duration, and treatment completion rate were all considered secondary objectives. RESULTS: 30 participants were eventually enrolled in the study,and the treatment completion rate was 80.0%. Most adverse events were in grades 1–2. Infusion response was the most frequent adverse event(24/30, 80%). The overall response rate was 80.0%(24/30). In 24 patients(80.0%), the fever persisted for 1 day. CONCLUSION: Treatment of invasive fungal illness in conjunction with hematological malignancies showed good efficacy and safety with amphotericin B cholesteryl sulfate complex for injection.