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Mediating effect assessment of ifosfamide on limb salvage rate in osteosarcoma: A study from a single center in China

Osteosarcoma is one of the most prevalent primary bone malignancies in children and adolescents. Surgery and chemotherapy are the standard treatment methods of osteosarcoma. Methotrexate, adriamycin, and cisplatin, and methotrexate, adriamycin, cisplatin, and ifosfamide regimens are both first-line...

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Autores principales: Li, Yan, Fu, Yiwei, Zhang, Zhaohui, Wang, Zhuo, Yin, Junqiang, Shen, Jingnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669720/
https://www.ncbi.nlm.nih.gov/pubmed/36408166
http://dx.doi.org/10.3389/fonc.2022.1046199
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author Li, Yan
Fu, Yiwei
Zhang, Zhaohui
Wang, Zhuo
Yin, Junqiang
Shen, Jingnan
author_facet Li, Yan
Fu, Yiwei
Zhang, Zhaohui
Wang, Zhuo
Yin, Junqiang
Shen, Jingnan
author_sort Li, Yan
collection PubMed
description Osteosarcoma is one of the most prevalent primary bone malignancies in children and adolescents. Surgery and chemotherapy are the standard treatment methods of osteosarcoma. Methotrexate, adriamycin, and cisplatin, and methotrexate, adriamycin, cisplatin, and ifosfamide regimens are both first-line neoadjuvant chemotherapy regimens for osteosarcoma. Moreover, the use of ifosfamide is highly controversial. Most studies of ifosfamide focused on the overall survival rate and event-free survival rate; few studies concentrated on surgical options. We conducted this retrospective study to compare the baseline characteristic of amputation and limb salvage osteosarcoma patients. Furthermore, we analyzed the direct and indirect roles in surgical decision-making and found that ifosfamide may play a partial mediating role in the surgery option choice by mediating tumor mass volume change, tumor response, and the shortest distance from the center of main blood vessels to the margin of the tumor lesion.
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spelling pubmed-96697202022-11-18 Mediating effect assessment of ifosfamide on limb salvage rate in osteosarcoma: A study from a single center in China Li, Yan Fu, Yiwei Zhang, Zhaohui Wang, Zhuo Yin, Junqiang Shen, Jingnan Front Oncol Oncology Osteosarcoma is one of the most prevalent primary bone malignancies in children and adolescents. Surgery and chemotherapy are the standard treatment methods of osteosarcoma. Methotrexate, adriamycin, and cisplatin, and methotrexate, adriamycin, cisplatin, and ifosfamide regimens are both first-line neoadjuvant chemotherapy regimens for osteosarcoma. Moreover, the use of ifosfamide is highly controversial. Most studies of ifosfamide focused on the overall survival rate and event-free survival rate; few studies concentrated on surgical options. We conducted this retrospective study to compare the baseline characteristic of amputation and limb salvage osteosarcoma patients. Furthermore, we analyzed the direct and indirect roles in surgical decision-making and found that ifosfamide may play a partial mediating role in the surgery option choice by mediating tumor mass volume change, tumor response, and the shortest distance from the center of main blood vessels to the margin of the tumor lesion. Frontiers Media S.A. 2022-11-03 /pmc/articles/PMC9669720/ /pubmed/36408166 http://dx.doi.org/10.3389/fonc.2022.1046199 Text en Copyright © 2022 Li, Fu, Zhang, Wang, Yin and Shen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Yan
Fu, Yiwei
Zhang, Zhaohui
Wang, Zhuo
Yin, Junqiang
Shen, Jingnan
Mediating effect assessment of ifosfamide on limb salvage rate in osteosarcoma: A study from a single center in China
title Mediating effect assessment of ifosfamide on limb salvage rate in osteosarcoma: A study from a single center in China
title_full Mediating effect assessment of ifosfamide on limb salvage rate in osteosarcoma: A study from a single center in China
title_fullStr Mediating effect assessment of ifosfamide on limb salvage rate in osteosarcoma: A study from a single center in China
title_full_unstemmed Mediating effect assessment of ifosfamide on limb salvage rate in osteosarcoma: A study from a single center in China
title_short Mediating effect assessment of ifosfamide on limb salvage rate in osteosarcoma: A study from a single center in China
title_sort mediating effect assessment of ifosfamide on limb salvage rate in osteosarcoma: a study from a single center in china
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669720/
https://www.ncbi.nlm.nih.gov/pubmed/36408166
http://dx.doi.org/10.3389/fonc.2022.1046199
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