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Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions
Cirrhosis causes a heavy global burden. In this review, we summarized up-to-date epidemiological features of cirrhosis and its complications. Recent epidemiological studies reported an increase in the prevalence of cirrhosis in 2017 compared to in 1990 in both men and women, with 5.2 million cases o...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669831/ https://www.ncbi.nlm.nih.gov/pubmed/36405106 http://dx.doi.org/10.3748/wjg.v28.i41.5910 |
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author | Liu, Yuan-Bin Chen, Ming-Kai |
author_facet | Liu, Yuan-Bin Chen, Ming-Kai |
author_sort | Liu, Yuan-Bin |
collection | PubMed |
description | Cirrhosis causes a heavy global burden. In this review, we summarized up-to-date epidemiological features of cirrhosis and its complications. Recent epidemiological studies reported an increase in the prevalence of cirrhosis in 2017 compared to in 1990 in both men and women, with 5.2 million cases of cirrhosis and chronic liver disease occurring in 2017. Cirrhosis caused 1.48 million deaths in 2019, an increase of 8.1% compared to 2017. Disability-adjusted life-years due to cirrhosis ranked 16th among all diseases and 7th in people aged 50-74 years in 2019. The global burden of hepatitis B virus and hepatitis C virus-associated cirrhosis is decreasing, while the burden of cirrhosis due to alcohol and nonalcoholic fatty liver disease (NAFLD) is increasing rapidly. We described the current epidemiology of the major complications of cirrhosis, including ascites, variceal bleeding, hepatic encephalopathy, renal disorders, and infections. We also summarized the epidemiology of hepatocellular carcinoma in patients with cirrhosis. In the future, NAFLD-related cirrhosis will likely become more common due to the prevalence of metabolic diseases such as obesity and diabetes, and the prevalence of alcohol-induced cirrhosis is increasing. This altered epidemiology should be clinically noted, and relevant interventions should be undertaken. |
format | Online Article Text |
id | pubmed-9669831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-96698312022-11-18 Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions Liu, Yuan-Bin Chen, Ming-Kai World J Gastroenterol Review Cirrhosis causes a heavy global burden. In this review, we summarized up-to-date epidemiological features of cirrhosis and its complications. Recent epidemiological studies reported an increase in the prevalence of cirrhosis in 2017 compared to in 1990 in both men and women, with 5.2 million cases of cirrhosis and chronic liver disease occurring in 2017. Cirrhosis caused 1.48 million deaths in 2019, an increase of 8.1% compared to 2017. Disability-adjusted life-years due to cirrhosis ranked 16th among all diseases and 7th in people aged 50-74 years in 2019. The global burden of hepatitis B virus and hepatitis C virus-associated cirrhosis is decreasing, while the burden of cirrhosis due to alcohol and nonalcoholic fatty liver disease (NAFLD) is increasing rapidly. We described the current epidemiology of the major complications of cirrhosis, including ascites, variceal bleeding, hepatic encephalopathy, renal disorders, and infections. We also summarized the epidemiology of hepatocellular carcinoma in patients with cirrhosis. In the future, NAFLD-related cirrhosis will likely become more common due to the prevalence of metabolic diseases such as obesity and diabetes, and the prevalence of alcohol-induced cirrhosis is increasing. This altered epidemiology should be clinically noted, and relevant interventions should be undertaken. Baishideng Publishing Group Inc 2022-11-07 2022-11-07 /pmc/articles/PMC9669831/ /pubmed/36405106 http://dx.doi.org/10.3748/wjg.v28.i41.5910 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Review Liu, Yuan-Bin Chen, Ming-Kai Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions |
title | Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions |
title_full | Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions |
title_fullStr | Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions |
title_full_unstemmed | Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions |
title_short | Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions |
title_sort | epidemiology of liver cirrhosis and associated complications: current knowledge and future directions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669831/ https://www.ncbi.nlm.nih.gov/pubmed/36405106 http://dx.doi.org/10.3748/wjg.v28.i41.5910 |
work_keys_str_mv | AT liuyuanbin epidemiologyoflivercirrhosisandassociatedcomplicationscurrentknowledgeandfuturedirections AT chenmingkai epidemiologyoflivercirrhosisandassociatedcomplicationscurrentknowledgeandfuturedirections |