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Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study

BACKGROUND: The progression of motor and non-motor symptoms (NMS) and the sensitivity of each item of the Unified Multiple System Atrophy Rating Scale (UMSARS) to change remain unclear in Chinese patients with early-stage multiple system atrophy (MSA). We investigated the evolution of motor symptoms...

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Autores principales: Zhang, Lingyu, Hou, Yanbing, Cao, Bei, Wei, Qianqian, Ou, Ruwei, Liu, Kuncheng, Lin, Junyu, Yang, Tianmi, Xiao, Yi, Chen, Yongping, Song, Wei, Zhao, Bi, Shang, Huifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670051/
https://www.ncbi.nlm.nih.gov/pubmed/36397048
http://dx.doi.org/10.1186/s12916-022-02645-1
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author Zhang, Lingyu
Hou, Yanbing
Cao, Bei
Wei, Qianqian
Ou, Ruwei
Liu, Kuncheng
Lin, Junyu
Yang, Tianmi
Xiao, Yi
Chen, Yongping
Song, Wei
Zhao, Bi
Shang, Huifang
author_facet Zhang, Lingyu
Hou, Yanbing
Cao, Bei
Wei, Qianqian
Ou, Ruwei
Liu, Kuncheng
Lin, Junyu
Yang, Tianmi
Xiao, Yi
Chen, Yongping
Song, Wei
Zhao, Bi
Shang, Huifang
author_sort Zhang, Lingyu
collection PubMed
description BACKGROUND: The progression of motor and non-motor symptoms (NMS) and the sensitivity of each item of the Unified Multiple System Atrophy Rating Scale (UMSARS) to change remain unclear in Chinese patients with early-stage multiple system atrophy (MSA). We investigated the evolution of motor symptoms and NMS in early-stage MSA and the sensitivity of each item included in the UMSARS to change over a 2-year follow-up. METHODS: Motor symptoms and NMS were recorded at baseline and at 1- and 2-year follow-ups based on the UMSARS and the NMS scale. Generalized estimating equation models were used. The sensitivity of an item included in the UMSARS to change was assessed by calculating a standardized effect using the mean annual change divided by the standard deviation of the change. RESULTS: We enrolled 246 consecutive patients with MSA and 97 MSA completed the 2-year follow-up. The mean total UMSARS score increased by 11.90 and 22.54 points at the 1- and 2-year follow-ups, respectively. UMSARS-I items associated with motor functions were more sensitive to change and those associated with autonomic dysfunction showed less sensitivity to change. Items 4 (tremor at rest), 5 (action tremor), and 3 (ocular motor dysfunction) of the UMSARS-II were less sensitive to change. The prevalence and severity of NMS significantly increased over the 2-year follow-up. CONCLUSIONS: We observed significant progression in motor symptoms and NMS in patients with early-stage MSA. Our results provide useful information to support the revision of the UMSARS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02645-1.
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spelling pubmed-96700512022-11-18 Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study Zhang, Lingyu Hou, Yanbing Cao, Bei Wei, Qianqian Ou, Ruwei Liu, Kuncheng Lin, Junyu Yang, Tianmi Xiao, Yi Chen, Yongping Song, Wei Zhao, Bi Shang, Huifang BMC Med Research Article BACKGROUND: The progression of motor and non-motor symptoms (NMS) and the sensitivity of each item of the Unified Multiple System Atrophy Rating Scale (UMSARS) to change remain unclear in Chinese patients with early-stage multiple system atrophy (MSA). We investigated the evolution of motor symptoms and NMS in early-stage MSA and the sensitivity of each item included in the UMSARS to change over a 2-year follow-up. METHODS: Motor symptoms and NMS were recorded at baseline and at 1- and 2-year follow-ups based on the UMSARS and the NMS scale. Generalized estimating equation models were used. The sensitivity of an item included in the UMSARS to change was assessed by calculating a standardized effect using the mean annual change divided by the standard deviation of the change. RESULTS: We enrolled 246 consecutive patients with MSA and 97 MSA completed the 2-year follow-up. The mean total UMSARS score increased by 11.90 and 22.54 points at the 1- and 2-year follow-ups, respectively. UMSARS-I items associated with motor functions were more sensitive to change and those associated with autonomic dysfunction showed less sensitivity to change. Items 4 (tremor at rest), 5 (action tremor), and 3 (ocular motor dysfunction) of the UMSARS-II were less sensitive to change. The prevalence and severity of NMS significantly increased over the 2-year follow-up. CONCLUSIONS: We observed significant progression in motor symptoms and NMS in patients with early-stage MSA. Our results provide useful information to support the revision of the UMSARS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02645-1. BioMed Central 2022-11-17 /pmc/articles/PMC9670051/ /pubmed/36397048 http://dx.doi.org/10.1186/s12916-022-02645-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zhang, Lingyu
Hou, Yanbing
Cao, Bei
Wei, Qianqian
Ou, Ruwei
Liu, Kuncheng
Lin, Junyu
Yang, Tianmi
Xiao, Yi
Chen, Yongping
Song, Wei
Zhao, Bi
Shang, Huifang
Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study
title Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study
title_full Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study
title_fullStr Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study
title_full_unstemmed Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study
title_short Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study
title_sort longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670051/
https://www.ncbi.nlm.nih.gov/pubmed/36397048
http://dx.doi.org/10.1186/s12916-022-02645-1
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