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The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study
To explore the causal relationship between maternal smoking around birth and childhood asthma using Mendelian randomization (MR). Using the data from large-scale genome-wide association studies, we selected independent genetic loci closely related to maternal smoking around birth and maternal diseas...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670139/ https://www.ncbi.nlm.nih.gov/pubmed/36408054 http://dx.doi.org/10.3389/fpubh.2022.1059195 |
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author | Ding, Zijun Pang, Lei Chai, Hongqiang Li, Fei Wu, Ming |
author_facet | Ding, Zijun Pang, Lei Chai, Hongqiang Li, Fei Wu, Ming |
author_sort | Ding, Zijun |
collection | PubMed |
description | To explore the causal relationship between maternal smoking around birth and childhood asthma using Mendelian randomization (MR). Using the data from large-scale genome-wide association studies, we selected independent genetic loci closely related to maternal smoking around birth and maternal diseases as instrumental variables and used MR methods. In this study, we considered the inverse variance weighted method (MR-IVW), weighted median method, and MR-Egger regression. We investigated the causal relationship between maternal smoking around birth and maternal diseases in childhood asthma using the odds ratio (OR) as an evaluation index. Multivariable MR (MVMR) included maternal history of Alzheimer's disease, illnesses of the mother: high blood pressure and illnesses of the mother: heart diseaseas covariates to address potential confounding. Sensitivity analyses were evaluated for weak instrument bias and pleiotropic effects. It was shown with the MR-IVW results that maternal smoking around birth increased the risk of childhood asthma by 1.5% (OR = 1.0150, 95% CI: 1.0018–1.0283). After the multivariable MR method was used to correct for relevant covariates, the association effect between maternal smoking around birth and childhood asthma was still statistically significant (P < 0.05). Maternal smoking around birth increases the risk of childhood asthma. |
format | Online Article Text |
id | pubmed-9670139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96701392022-11-18 The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study Ding, Zijun Pang, Lei Chai, Hongqiang Li, Fei Wu, Ming Front Public Health Public Health To explore the causal relationship between maternal smoking around birth and childhood asthma using Mendelian randomization (MR). Using the data from large-scale genome-wide association studies, we selected independent genetic loci closely related to maternal smoking around birth and maternal diseases as instrumental variables and used MR methods. In this study, we considered the inverse variance weighted method (MR-IVW), weighted median method, and MR-Egger regression. We investigated the causal relationship between maternal smoking around birth and maternal diseases in childhood asthma using the odds ratio (OR) as an evaluation index. Multivariable MR (MVMR) included maternal history of Alzheimer's disease, illnesses of the mother: high blood pressure and illnesses of the mother: heart diseaseas covariates to address potential confounding. Sensitivity analyses were evaluated for weak instrument bias and pleiotropic effects. It was shown with the MR-IVW results that maternal smoking around birth increased the risk of childhood asthma by 1.5% (OR = 1.0150, 95% CI: 1.0018–1.0283). After the multivariable MR method was used to correct for relevant covariates, the association effect between maternal smoking around birth and childhood asthma was still statistically significant (P < 0.05). Maternal smoking around birth increases the risk of childhood asthma. Frontiers Media S.A. 2022-11-03 /pmc/articles/PMC9670139/ /pubmed/36408054 http://dx.doi.org/10.3389/fpubh.2022.1059195 Text en Copyright © 2022 Ding, Pang, Chai, Li and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Ding, Zijun Pang, Lei Chai, Hongqiang Li, Fei Wu, Ming The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study |
title | The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study |
title_full | The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study |
title_fullStr | The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study |
title_full_unstemmed | The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study |
title_short | The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study |
title_sort | causal association between maternal smoking around birth on childhood asthma: a mendelian randomization study |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670139/ https://www.ncbi.nlm.nih.gov/pubmed/36408054 http://dx.doi.org/10.3389/fpubh.2022.1059195 |
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