Cargando…

Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases

Medical ozone reestablishes cellular redox balance so that it may be a valid therapeutic approach in the prevention and management of age-related diseases with oxidative etiology in older people. The aim of this study is to evaluate oxidative stress and some vasoactive substances in elderly (60–70 y...

Descripción completa

Detalles Bibliográficos
Autores principales: León Fernández, Olga Sonia, Oru, Gabriel Takon, Viebahn-Hänsler, Renate, López Cabreja, Gilberto, Serrano Espinosa, Irainis, García Fernández, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670171/
https://www.ncbi.nlm.nih.gov/pubmed/36406985
http://dx.doi.org/10.3389/fphys.2022.1029805
_version_ 1784832282990739456
author León Fernández, Olga Sonia
Oru, Gabriel Takon
Viebahn-Hänsler, Renate
López Cabreja, Gilberto
Serrano Espinosa, Irainis
García Fernández, Elizabeth
author_facet León Fernández, Olga Sonia
Oru, Gabriel Takon
Viebahn-Hänsler, Renate
López Cabreja, Gilberto
Serrano Espinosa, Irainis
García Fernández, Elizabeth
author_sort León Fernández, Olga Sonia
collection PubMed
description Medical ozone reestablishes cellular redox balance so that it may be a valid therapeutic approach in the prevention and management of age-related diseases with oxidative etiology in older people. The aim of this study is to evaluate oxidative stress and some vasoactive substances in elderly (60–70 years) rheumatoid arthritis patients with diabetes and hypertension, as well as another group with bronchial asthma patients in order to demonstrate the beneficial effects of medical ozone in the prevention and therapy of age-related diseases in these age groups. A randomized clinical study with 45 older patients (60–70 years) was performed. Group I (n = 15) with rheumatoid arthritis + diabetes and hypertension received no ozone treatment, and group II (n = 30) was treated with medical ozone. This group was divided into two subgroups (n = 15 each), group IIa: the same as group I + medical ozone and group IIb: bronchial asthma patients. Indicators of RA in I and IIa groups were evaluated. Redox balance was assessed through defense and injury biomarkers. Thromboxane A2 (TXA2) and prostacyclin levels were assessed in group IIb patients. Medical ozone arrested oxidative injury progression in the Ia group and decreased thromboxane levels and the TXA2/6-keto PGF1α ratio in the IIb group. Medical ozone arrested the progression of oxidative damage and modulated those endogenous mechanisms that promote a suitable redox status and TXA2/PGI2 balance. These results suggest that medical ozone may become a standard approach in the prevention and management of age-related oxidative diseases in elderly people.
format Online
Article
Text
id pubmed-9670171
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96701712022-11-18 Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases León Fernández, Olga Sonia Oru, Gabriel Takon Viebahn-Hänsler, Renate López Cabreja, Gilberto Serrano Espinosa, Irainis García Fernández, Elizabeth Front Physiol Physiology Medical ozone reestablishes cellular redox balance so that it may be a valid therapeutic approach in the prevention and management of age-related diseases with oxidative etiology in older people. The aim of this study is to evaluate oxidative stress and some vasoactive substances in elderly (60–70 years) rheumatoid arthritis patients with diabetes and hypertension, as well as another group with bronchial asthma patients in order to demonstrate the beneficial effects of medical ozone in the prevention and therapy of age-related diseases in these age groups. A randomized clinical study with 45 older patients (60–70 years) was performed. Group I (n = 15) with rheumatoid arthritis + diabetes and hypertension received no ozone treatment, and group II (n = 30) was treated with medical ozone. This group was divided into two subgroups (n = 15 each), group IIa: the same as group I + medical ozone and group IIb: bronchial asthma patients. Indicators of RA in I and IIa groups were evaluated. Redox balance was assessed through defense and injury biomarkers. Thromboxane A2 (TXA2) and prostacyclin levels were assessed in group IIb patients. Medical ozone arrested oxidative injury progression in the Ia group and decreased thromboxane levels and the TXA2/6-keto PGF1α ratio in the IIb group. Medical ozone arrested the progression of oxidative damage and modulated those endogenous mechanisms that promote a suitable redox status and TXA2/PGI2 balance. These results suggest that medical ozone may become a standard approach in the prevention and management of age-related oxidative diseases in elderly people. Frontiers Media S.A. 2022-11-03 /pmc/articles/PMC9670171/ /pubmed/36406985 http://dx.doi.org/10.3389/fphys.2022.1029805 Text en Copyright © 2022 León Fernández, Oru, Viebahn-Hänsler, López Cabreja, Serrano Espinosa and García Fernández. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
León Fernández, Olga Sonia
Oru, Gabriel Takon
Viebahn-Hänsler, Renate
López Cabreja, Gilberto
Serrano Espinosa, Irainis
García Fernández, Elizabeth
Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases
title Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases
title_full Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases
title_fullStr Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases
title_full_unstemmed Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases
title_short Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases
title_sort medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670171/
https://www.ncbi.nlm.nih.gov/pubmed/36406985
http://dx.doi.org/10.3389/fphys.2022.1029805
work_keys_str_mv AT leonfernandezolgasonia medicalozonearrestsoxidativedamageprogressionandregulatesvasoactivemediatorlevelsinelderlypatients6070yearswithoxidativeetiologydiseases
AT orugabrieltakon medicalozonearrestsoxidativedamageprogressionandregulatesvasoactivemediatorlevelsinelderlypatients6070yearswithoxidativeetiologydiseases
AT viebahnhanslerrenate medicalozonearrestsoxidativedamageprogressionandregulatesvasoactivemediatorlevelsinelderlypatients6070yearswithoxidativeetiologydiseases
AT lopezcabrejagilberto medicalozonearrestsoxidativedamageprogressionandregulatesvasoactivemediatorlevelsinelderlypatients6070yearswithoxidativeetiologydiseases
AT serranoespinosairainis medicalozonearrestsoxidativedamageprogressionandregulatesvasoactivemediatorlevelsinelderlypatients6070yearswithoxidativeetiologydiseases
AT garciafernandezelizabeth medicalozonearrestsoxidativedamageprogressionandregulatesvasoactivemediatorlevelsinelderlypatients6070yearswithoxidativeetiologydiseases