Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism

The ribonuclease DIS3 is one of the most frequently mutated genes in the hematological cancer multiple myeloma, yet the basis of its tumor suppressor function in this disease remains unclear. Herein, exploiting the TCGA dataset, we found that DIS3 plays a prominent role in the DNA damage response. D...

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Detalles Bibliográficos
Autores principales: Gritti, Ilaria, Basso, Veronica, Rinchai, Darawan, Corigliano, Federica, Pivetti, Silvia, Gaviraghi, Marco, Rosano, Dalia, Mazza, Davide, Barozzi, Sara, Roncador, Marco, Parmigiani, Giovanni, Legube, Gaelle, Parazzoli, Dario, Cittaro, Davide, Bedognetti, Davide, Mondino, Anna, Segalla, Simona, Tonon, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670201/
https://www.ncbi.nlm.nih.gov/pubmed/36215697
http://dx.doi.org/10.15252/embj.2021108040

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