Oxidative stress‐induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2

Retrograde transport of lysosomes is recognised as a critical autophagy regulator. Here, we found that acrolein, an aldehyde that is significantly elevated in Parkinson's disease patient serum, enhances autophagy by promoting lysosomal clustering around the microtubule organising centre via a n...

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Detalles Bibliográficos
Autores principales: Sasazawa, Yukiko, Souma, Sanae, Furuya, Norihiko, Miura, Yoshiki, Kazuno, Saiko, Kakuta, Soichiro, Suzuki, Ayami, Hashimoto, Ryota, Hirawake‐Mogi, Hiroko, Date, Yuki, Imoto, Masaya, Ueno, Takashi, Kataura, Tetsushi, Korolchuk, Viktor I, Tsunemi, Taiji, Hattori, Nobutaka, Saiki, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670204/
https://www.ncbi.nlm.nih.gov/pubmed/36394115
http://dx.doi.org/10.15252/embj.2022111476

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