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Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort
BACKGROUND: The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index knees and to describe change for different MRI features based on number of subregion-app...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670371/ https://www.ncbi.nlm.nih.gov/pubmed/36397054 http://dx.doi.org/10.1186/s12891-022-05926-1 |
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author | Roemer, Frank W. Jansen, Mylène Marijnissen, Anne C. A. Guermazi, Ali Heiss, Rafael Maschek, Susanne Lalande, Agnes Blanco, Francisco J. Berenbaum, Francis van de Stadt, Lotte A. Kloppenburg, Margreet Haugen, Ida K. Ladel, Christoph H. Bacardit, Jaume Wisser, Anna Eckstein, Felix Lafeber, Floris P. J. G. Weinans, Harrie H. Wirth, Wolfgang |
author_facet | Roemer, Frank W. Jansen, Mylène Marijnissen, Anne C. A. Guermazi, Ali Heiss, Rafael Maschek, Susanne Lalande, Agnes Blanco, Francisco J. Berenbaum, Francis van de Stadt, Lotte A. Kloppenburg, Margreet Haugen, Ida K. Ladel, Christoph H. Bacardit, Jaume Wisser, Anna Eckstein, Felix Lafeber, Floris P. J. G. Weinans, Harrie H. Wirth, Wolfgang |
author_sort | Roemer, Frank W. |
collection | PubMed |
description | BACKGROUND: The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index knees and to describe change for different MRI features based on number of subregion-approaches and change in maximum grades over a 24-month period. METHODS: MRIs were acquired using 1.5 T or 3 T MRI systems and assessed using the semi-quantitative MRI OA Knee Scoring (MOAKS) system. MRIs were read at baseline and 24-months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. In descriptive fashion, the frequencies of MRI features at baseline and change in these imaging biomarkers over time are presented for the entire sample in a subregional and maximum score approach for most features. Differences between knees without and with structural radiographic (R) OA are analyzed in addition. RESULTS: Two hundred eighty-nine participants had readable baseline MRI examinations. Mean age was 66.6 ± 7.1 years and participants had a mean BMI of 28.1 ± 5.3 kg/m(2). The majority (55.3%) of included knees had radiographic OA. Any change in total cartilage MOAKS score was observed in 53.1% considering full-grade changes only, and in 73.9% including full-grade and within-grade changes. Any medial cartilage progression was seen in 23.9% and any lateral progression on 22.1%. While for the medial and lateral compartments numbers of subregions with improvement and worsening of BMLs were very similar, for the PFJ more improvement was observed compared to worsening (15.5% vs. 9.0%). Including within grade changes, the number of knees showing BML worsening increased from 42.2% to 55.6%. While for some features 24-months change was rare, frequency of change was much more common in knees with vs. without ROA (e.g. worsening of total MOAKS score cartilage in 68.4% of ROA knees vs. 36.7% of no-ROA knees, and 60.7% vs. 21.8% for an increase in maximum BML score per knee). CONCLUSIONS: A wide range of MRI-detected structural pathologies was present in the IMI-APPROACH cohort. Baseline prevalence and change of features was substantially more common in the ROA subgroup compared to the knees without ROA. TRIAL REGISTRATION: Clinicaltrials.gov identification: NCT03883568. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-022-05926-1. |
format | Online Article Text |
id | pubmed-9670371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-96703712022-11-18 Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort Roemer, Frank W. Jansen, Mylène Marijnissen, Anne C. A. Guermazi, Ali Heiss, Rafael Maschek, Susanne Lalande, Agnes Blanco, Francisco J. Berenbaum, Francis van de Stadt, Lotte A. Kloppenburg, Margreet Haugen, Ida K. Ladel, Christoph H. Bacardit, Jaume Wisser, Anna Eckstein, Felix Lafeber, Floris P. J. G. Weinans, Harrie H. Wirth, Wolfgang BMC Musculoskelet Disord Research BACKGROUND: The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index knees and to describe change for different MRI features based on number of subregion-approaches and change in maximum grades over a 24-month period. METHODS: MRIs were acquired using 1.5 T or 3 T MRI systems and assessed using the semi-quantitative MRI OA Knee Scoring (MOAKS) system. MRIs were read at baseline and 24-months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. In descriptive fashion, the frequencies of MRI features at baseline and change in these imaging biomarkers over time are presented for the entire sample in a subregional and maximum score approach for most features. Differences between knees without and with structural radiographic (R) OA are analyzed in addition. RESULTS: Two hundred eighty-nine participants had readable baseline MRI examinations. Mean age was 66.6 ± 7.1 years and participants had a mean BMI of 28.1 ± 5.3 kg/m(2). The majority (55.3%) of included knees had radiographic OA. Any change in total cartilage MOAKS score was observed in 53.1% considering full-grade changes only, and in 73.9% including full-grade and within-grade changes. Any medial cartilage progression was seen in 23.9% and any lateral progression on 22.1%. While for the medial and lateral compartments numbers of subregions with improvement and worsening of BMLs were very similar, for the PFJ more improvement was observed compared to worsening (15.5% vs. 9.0%). Including within grade changes, the number of knees showing BML worsening increased from 42.2% to 55.6%. While for some features 24-months change was rare, frequency of change was much more common in knees with vs. without ROA (e.g. worsening of total MOAKS score cartilage in 68.4% of ROA knees vs. 36.7% of no-ROA knees, and 60.7% vs. 21.8% for an increase in maximum BML score per knee). CONCLUSIONS: A wide range of MRI-detected structural pathologies was present in the IMI-APPROACH cohort. Baseline prevalence and change of features was substantially more common in the ROA subgroup compared to the knees without ROA. TRIAL REGISTRATION: Clinicaltrials.gov identification: NCT03883568. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-022-05926-1. BioMed Central 2022-11-17 /pmc/articles/PMC9670371/ /pubmed/36397054 http://dx.doi.org/10.1186/s12891-022-05926-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Roemer, Frank W. Jansen, Mylène Marijnissen, Anne C. A. Guermazi, Ali Heiss, Rafael Maschek, Susanne Lalande, Agnes Blanco, Francisco J. Berenbaum, Francis van de Stadt, Lotte A. Kloppenburg, Margreet Haugen, Ida K. Ladel, Christoph H. Bacardit, Jaume Wisser, Anna Eckstein, Felix Lafeber, Floris P. J. G. Weinans, Harrie H. Wirth, Wolfgang Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort |
title | Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort |
title_full | Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort |
title_fullStr | Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort |
title_full_unstemmed | Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort |
title_short | Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort |
title_sort | structural tissue damage and 24-month progression of semi-quantitative mri biomarkers of knee osteoarthritis in the imi-approach cohort |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670371/ https://www.ncbi.nlm.nih.gov/pubmed/36397054 http://dx.doi.org/10.1186/s12891-022-05926-1 |
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