SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal

A novel recombinant SIRPα-Fc fusion protein, IMM01, was constructed and produced using an in-house developed CHO-K1 cell expression system, and the anti-tumor mechanism of IMM01 targeting the CD47-SIRPα pathway was explored. The phagocytosis and in vitro anti-tumor activity of IMM01 were evaluated b...

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Detalles Bibliográficos
Autores principales: Yu, Jifeng, Li, Song, Chen, Dianze, Liu, Dandan, Guo, Huiqin, Yang, Chunmei, Zhang, Wei, Zhang, Li, Zhao, Gui, Tu, Xiaoping, Peng, Liang, Liu, Sijin, Bai, Xing, Song, Yongping, Jiang, Zhongxing, Zhang, Ruliang, Tian, Wenzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670587/
https://www.ncbi.nlm.nih.gov/pubmed/36384978
http://dx.doi.org/10.1186/s13045-022-01385-2

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