Granulomatous interstitial nephritis with CTLA-4 haploinsufficiency: a case report

BACKGROUND: Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential inhibitory regulator of immune activation. CTLA-4 haploinsufficiency is known to be associated with dysregulation of FOXP3(+) regulatory T cells, hyperactivation of effector T cells, and lymphocytic infiltration of multiple organs...

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Detalles Bibliográficos
Autores principales: Kohatsu, Kaori, Suzuki, Tomo, Takimoto, Madoka, Matsui, Katsuomi, Hashiguchi, Akinori, Koike, Junki, Shirai, Sayuri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670605/
https://www.ncbi.nlm.nih.gov/pubmed/36384506
http://dx.doi.org/10.1186/s12882-022-02999-x

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