Chemodivergent Synthesis of Aza-Heterocycles with a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes and α-Bromo Carbonyl Compounds

[Image: see text] An efficient [4 + 1] annulation reaction between in situ generated azoalkene intermediates and α-bromocarbonyls has been established. A series of skeletally diverse aza-heterocycles with a functionalized quaternary center were obtained in up to 89% yield under mild conditions.

Detalles Bibliográficos
Autores principales: Zhang, Xiaoke, Wang, Haibo, Li, Ziwei, Shu, Yan, Gan, Song, Zhang, Xuefang, Shao, Huawu, Wang, Chaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670695/
https://www.ncbi.nlm.nih.gov/pubmed/36406503
http://dx.doi.org/10.1021/acsomega.2c04127
Descripción
Sumario:[Image: see text] An efficient [4 + 1] annulation reaction between in situ generated azoalkene intermediates and α-bromocarbonyls has been established. A series of skeletally diverse aza-heterocycles with a functionalized quaternary center were obtained in up to 89% yield under mild conditions.

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