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Chemodivergent Synthesis of Aza-Heterocycles with a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes and α-Bromo Carbonyl Compounds
[Image: see text] An efficient [4 + 1] annulation reaction between in situ generated azoalkene intermediates and α-bromocarbonyls has been established. A series of skeletally diverse aza-heterocycles with a functionalized quaternary center were obtained in up to 89% yield under mild conditions.
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670695/ https://www.ncbi.nlm.nih.gov/pubmed/36406503 http://dx.doi.org/10.1021/acsomega.2c04127 |
| _version_ | 1784832386982215680 |
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| author | Zhang, Xiaoke Wang, Haibo Li, Ziwei Shu, Yan Gan, Song Zhang, Xuefang Shao, Huawu Wang, Chaoyong |
| author_facet | Zhang, Xiaoke Wang, Haibo Li, Ziwei Shu, Yan Gan, Song Zhang, Xuefang Shao, Huawu Wang, Chaoyong |
| author_sort | Zhang, Xiaoke |
| collection | PubMed |
| description | [Image: see text] An efficient [4 + 1] annulation reaction between in situ generated azoalkene intermediates and α-bromocarbonyls has been established. A series of skeletally diverse aza-heterocycles with a functionalized quaternary center were obtained in up to 89% yield under mild conditions. |
| format | Online Article Text |
| id | pubmed-9670695 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-96706952022-11-18 Chemodivergent Synthesis of Aza-Heterocycles with a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes and α-Bromo Carbonyl Compounds Zhang, Xiaoke Wang, Haibo Li, Ziwei Shu, Yan Gan, Song Zhang, Xuefang Shao, Huawu Wang, Chaoyong ACS Omega [Image: see text] An efficient [4 + 1] annulation reaction between in situ generated azoalkene intermediates and α-bromocarbonyls has been established. A series of skeletally diverse aza-heterocycles with a functionalized quaternary center were obtained in up to 89% yield under mild conditions. American Chemical Society 2022-11-01 /pmc/articles/PMC9670695/ /pubmed/36406503 http://dx.doi.org/10.1021/acsomega.2c04127 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Zhang, Xiaoke Wang, Haibo Li, Ziwei Shu, Yan Gan, Song Zhang, Xuefang Shao, Huawu Wang, Chaoyong Chemodivergent Synthesis of Aza-Heterocycles with a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes and α-Bromo Carbonyl Compounds |
| title | Chemodivergent
Synthesis of Aza-Heterocycles with
a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes
and α-Bromo Carbonyl Compounds |
| title_full | Chemodivergent
Synthesis of Aza-Heterocycles with
a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes
and α-Bromo Carbonyl Compounds |
| title_fullStr | Chemodivergent
Synthesis of Aza-Heterocycles with
a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes
and α-Bromo Carbonyl Compounds |
| title_full_unstemmed | Chemodivergent
Synthesis of Aza-Heterocycles with
a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes
and α-Bromo Carbonyl Compounds |
| title_short | Chemodivergent
Synthesis of Aza-Heterocycles with
a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes
and α-Bromo Carbonyl Compounds |
| title_sort | chemodivergent
synthesis of aza-heterocycles with
a quarternary carbon center via [4 + 1] annulation between azoalkenes
and α-bromo carbonyl compounds |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670695/ https://www.ncbi.nlm.nih.gov/pubmed/36406503 http://dx.doi.org/10.1021/acsomega.2c04127 |
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