Cargando…
Co-Exposure of Ambient Particulate Matter and Airborne Transmission Pathogens: The Impairment of the Upper Respiratory Systems
[Image: see text] Recent evidence has pinpointed the positive relevance between air particulate matter (PM) pollution and epidemic spread. However, there are still significant knowledge gaps in understanding the transmission and infection of pathogens loaded on PMs, for example, the interactions bet...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670849/ https://www.ncbi.nlm.nih.gov/pubmed/36240448 http://dx.doi.org/10.1021/acs.est.2c03856 |
_version_ | 1784832419781672960 |
---|---|
author | Qi, Yu Chen, Yucai Yan, Xu Liu, Wei Ma, Li Liu, Yongchun Ma, Qingxin Liu, Sijin |
author_facet | Qi, Yu Chen, Yucai Yan, Xu Liu, Wei Ma, Li Liu, Yongchun Ma, Qingxin Liu, Sijin |
author_sort | Qi, Yu |
collection | PubMed |
description | [Image: see text] Recent evidence has pinpointed the positive relevance between air particulate matter (PM) pollution and epidemic spread. However, there are still significant knowledge gaps in understanding the transmission and infection of pathogens loaded on PMs, for example, the interactions between pathogens and pre-existing atmospheric PM and the health effects of co-exposure on the inhalation systems. Here, we unraveled the interactions between fine particulate matter (FPM) and Pseudomonas aeruginosa (P. aeruginosa) and evaluated the infection and detrimental effects of co-exposure on the upper respiratory systems in both in vitro and in vivo models. We uncovered the higher accessibility and invasive ability of pathogens to epithelial cells after loading on FPMs, compared with the single exposure. Furthermore, we designed a novel laboratory exposure model to simulate a real co-exposure scenario. Intriguingly, the co-exposure induced more serious functional damage and longer inflammatory reactions to the upper respiratory tract, including the nasal cavity and trachea. Collectively, our results provide a new point of view on the transmission and infection of pathogens loaded on FPMs and uncover the in vivo systematic impairments of the inhalation tract under co-exposure through a novel laboratory exposure model. Hence, this study sheds light on further investigations of the detrimental effects of air pollution and epidemic spread. |
format | Online Article Text |
id | pubmed-9670849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-96708492022-11-18 Co-Exposure of Ambient Particulate Matter and Airborne Transmission Pathogens: The Impairment of the Upper Respiratory Systems Qi, Yu Chen, Yucai Yan, Xu Liu, Wei Ma, Li Liu, Yongchun Ma, Qingxin Liu, Sijin Environ Sci Technol [Image: see text] Recent evidence has pinpointed the positive relevance between air particulate matter (PM) pollution and epidemic spread. However, there are still significant knowledge gaps in understanding the transmission and infection of pathogens loaded on PMs, for example, the interactions between pathogens and pre-existing atmospheric PM and the health effects of co-exposure on the inhalation systems. Here, we unraveled the interactions between fine particulate matter (FPM) and Pseudomonas aeruginosa (P. aeruginosa) and evaluated the infection and detrimental effects of co-exposure on the upper respiratory systems in both in vitro and in vivo models. We uncovered the higher accessibility and invasive ability of pathogens to epithelial cells after loading on FPMs, compared with the single exposure. Furthermore, we designed a novel laboratory exposure model to simulate a real co-exposure scenario. Intriguingly, the co-exposure induced more serious functional damage and longer inflammatory reactions to the upper respiratory tract, including the nasal cavity and trachea. Collectively, our results provide a new point of view on the transmission and infection of pathogens loaded on FPMs and uncover the in vivo systematic impairments of the inhalation tract under co-exposure through a novel laboratory exposure model. Hence, this study sheds light on further investigations of the detrimental effects of air pollution and epidemic spread. American Chemical Society 2022-10-14 2022-11-15 /pmc/articles/PMC9670849/ /pubmed/36240448 http://dx.doi.org/10.1021/acs.est.2c03856 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Qi, Yu Chen, Yucai Yan, Xu Liu, Wei Ma, Li Liu, Yongchun Ma, Qingxin Liu, Sijin Co-Exposure of Ambient Particulate Matter and Airborne Transmission Pathogens: The Impairment of the Upper Respiratory Systems |
title | Co-Exposure of Ambient
Particulate Matter and Airborne
Transmission Pathogens: The Impairment of the Upper Respiratory Systems |
title_full | Co-Exposure of Ambient
Particulate Matter and Airborne
Transmission Pathogens: The Impairment of the Upper Respiratory Systems |
title_fullStr | Co-Exposure of Ambient
Particulate Matter and Airborne
Transmission Pathogens: The Impairment of the Upper Respiratory Systems |
title_full_unstemmed | Co-Exposure of Ambient
Particulate Matter and Airborne
Transmission Pathogens: The Impairment of the Upper Respiratory Systems |
title_short | Co-Exposure of Ambient
Particulate Matter and Airborne
Transmission Pathogens: The Impairment of the Upper Respiratory Systems |
title_sort | co-exposure of ambient
particulate matter and airborne
transmission pathogens: the impairment of the upper respiratory systems |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670849/ https://www.ncbi.nlm.nih.gov/pubmed/36240448 http://dx.doi.org/10.1021/acs.est.2c03856 |
work_keys_str_mv | AT qiyu coexposureofambientparticulatematterandairbornetransmissionpathogenstheimpairmentoftheupperrespiratorysystems AT chenyucai coexposureofambientparticulatematterandairbornetransmissionpathogenstheimpairmentoftheupperrespiratorysystems AT yanxu coexposureofambientparticulatematterandairbornetransmissionpathogenstheimpairmentoftheupperrespiratorysystems AT liuwei coexposureofambientparticulatematterandairbornetransmissionpathogenstheimpairmentoftheupperrespiratorysystems AT mali coexposureofambientparticulatematterandairbornetransmissionpathogenstheimpairmentoftheupperrespiratorysystems AT liuyongchun coexposureofambientparticulatematterandairbornetransmissionpathogenstheimpairmentoftheupperrespiratorysystems AT maqingxin coexposureofambientparticulatematterandairbornetransmissionpathogenstheimpairmentoftheupperrespiratorysystems AT liusijin coexposureofambientparticulatematterandairbornetransmissionpathogenstheimpairmentoftheupperrespiratorysystems |