Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy

In “healthy” tumor cells, phosphatidylserine (PS) is predominately localized in the inner plasma membrane leaflet. During apoptosis, PS relocates to the outer leaflet. Herein, we established PS(out) tumor models with tumor cells lacking PS flippase component CDC50A, constantly exposing PS but alive....

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Detalles Bibliográficos
Autores principales: Wang, Weihong, Wu, Shaoxian, Cen, Zhanpeng, Zhang, Yixin, Chen, Yuang, Huang, Yixian, Cillo, Anthony R., Prokopec, Joshua S., Quarato, Giovanni, Vignali, Dario A.A., Stewart-Ornstein, Jacob, Li, Song, Lu, Binfeng, Gong, Yi-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671066/
https://www.ncbi.nlm.nih.gov/pubmed/36323258
http://dx.doi.org/10.1016/j.celrep.2022.111582

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