Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors

Broadly neutralizing antibodies (bnAbs) to the HIV envelope (Env) V2-apex region are important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an uncommonly long heavy-chain complementarity-determining region 3 (HCDR3), suggesting that the rarity of bnAb precursors poses a challenge...

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Detalles Bibliográficos
Autores principales: Willis, Jordan R., Berndsen, Zachary T., Ma, Krystal M., Steichen, Jon M., Schiffner, Torben, Landais, Elise, Liguori, Alessia, Kalyuzhniy, Oleksandr, Allen, Joel D., Baboo, Sabyasachi, Omorodion, Oluwarotimi, Diedrich, Jolene K., Hu, Xiaozhen, Georgeson, Erik, Phelps, Nicole, Eskandarzadeh, Saman, Groschel, Bettina, Kubitz, Michael, Adachi, Yumiko, Mullin, Tina-Marie, Alavi, Nushin B., Falcone, Samantha, Himansu, Sunny, Carfi, Andrea, Wilson, Ian A., Yates, John R., Paulson, James C., Crispin, Max, Ward, Andrew B., Schief, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671094/
https://www.ncbi.nlm.nih.gov/pubmed/36179689
http://dx.doi.org/10.1016/j.immuni.2022.09.001

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