Autoimmunity: Are we asking the right question?

For decades, the main question immunologists have asked about autoimmunity is “what causes a break in self-tolerance?” We have not found good answers to that question, and I believe we are still so ignorant because it’s the wrong question. Rather than a break in self-tolerance, I suggest that many a...

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Detalles Bibliográficos
Autor principal: Matzinger, Polly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671104/
https://www.ncbi.nlm.nih.gov/pubmed/36405714
http://dx.doi.org/10.3389/fimmu.2022.864633
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author Matzinger, Polly
author_facet Matzinger, Polly
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description For decades, the main question immunologists have asked about autoimmunity is “what causes a break in self-tolerance?” We have not found good answers to that question, and I believe we are still so ignorant because it’s the wrong question. Rather than a break in self-tolerance, I suggest that many autoimmune diseases might be due to defects in normal tissue physiology.
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spelling pubmed-96711042022-11-18 Autoimmunity: Are we asking the right question? Matzinger, Polly Front Immunol Immunology For decades, the main question immunologists have asked about autoimmunity is “what causes a break in self-tolerance?” We have not found good answers to that question, and I believe we are still so ignorant because it’s the wrong question. Rather than a break in self-tolerance, I suggest that many autoimmune diseases might be due to defects in normal tissue physiology. Frontiers Media S.A. 2022-11-03 /pmc/articles/PMC9671104/ /pubmed/36405714 http://dx.doi.org/10.3389/fimmu.2022.864633 Text en Copyright © 2022 Matzinger https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Matzinger, Polly
Autoimmunity: Are we asking the right question?
title Autoimmunity: Are we asking the right question?
title_full Autoimmunity: Are we asking the right question?
title_fullStr Autoimmunity: Are we asking the right question?
title_full_unstemmed Autoimmunity: Are we asking the right question?
title_short Autoimmunity: Are we asking the right question?
title_sort autoimmunity: are we asking the right question?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671104/
https://www.ncbi.nlm.nih.gov/pubmed/36405714
http://dx.doi.org/10.3389/fimmu.2022.864633
work_keys_str_mv AT matzingerpolly autoimmunityareweaskingtherightquestion

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